TNFRSF10B Protein (AA 52-212, Extracellular Domain) (Fc Tag)
-
- Target See all TNFRSF10B Proteins
- TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- Extracellular Domain, AA 52-212
-
Origin
- Human, Mouse
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TNFRSF10B protein is labelled with Fc Tag.
- Application
- SDS-PAGE (SDS)
- Specificity
- Binds to human and mouse TRAIL.
- Cross-Reactivity
- Human, Mouse (Murine)
- Characteristics
- The extracellular domain of human TRAIL-R2 (aa 52-212) is fused to the Fc portion of human IgG1.
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product TNFRSF10B Protein
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
-
Blocks human or mouse TRAIL activity in a concentration of 1-10μg/ml.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Reconstitute with 50 μL sterile water.
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Storage
- 4 °C,-20 °C
- Storage Comment
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Expiry Date
- 6 months
-
- Target
- TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
- Alternative Name
- TRAIL-R2 (TNFRSF10B Products)
- Synonyms
- TNFRSF10B Protein, dr5 Protein, cd262 Protein, killer Protein, trick2 Protein, trickb Protein, xDR-M1 Protein, xDR-M2 Protein, ztnfr9 Protein, trailr2 Protein, trick2a Protein, trick2b Protein, CD262 Protein, DR5 Protein, KILLER Protein, KILLER/DR5 Protein, TRAIL-R2 Protein, TRAILR2 Protein, TRICK2 Protein, TRICK2A Protein, TRICK2B Protein, TRICKB Protein, ZTNFR9 Protein, Ly98 Protein, MK Protein, tumor necrosis factor receptor superfamily, member 10b Protein, tumor necrosis factor receptor superfamily member 10b S homeolog Protein, tumor necrosis factor receptor superfamily member 10b L homeolog Protein, tumor necrosis factor receptor superfamily member 10b Protein, TNF receptor superfamily member 10b Protein, Tnfrsf10b Protein, TNFRSF10B Protein, tnfrsf10b.S Protein, tnfrsf10b.L Protein, tnfrsf10b Protein
- Background
- TRAIL-R2 (DR5, CD262) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
- Molecular Weight
- ~50kDa (SDS-PAGE)
- UniProt
- O14763
- Pathways
- p53 Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity
-