FAS Protein (AA 26-172)
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- Target See all FAS Proteins
- FAS (TNF Receptor Superfamily, Member 6 (FAS))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 26-172
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Origin
- Human
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Source
- HEK-293T Cells
- Characteristics
- ED50 <0.4 μg/mL, measured by its ability to inhibit the cytotoxicity of Jurkat cells in the presence of 20 ng/mL of human Fas Ligand.
- Purity
- > 95 % as analyzed by SDS-PAGE.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
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- Discover our top product FAS Protein
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TNF Receptor Superfamily, Member 6 (FAS) (AA 26-173) protein (Fc Tag)
FAS Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
TNF Receptor Superfamily, Member 6 (FAS) (AA 22-169) protein (Fc Tag)FAS Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
TNF Receptor Superfamily, Member 6 (FAS) (AA 26-173) protein (His tag)FAS Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
TNF Receptor Superfamily, Member 6 (FAS) (AA 25-169) protein (His-DYKDDDDK-Strep II Tag)FAS Origin: Human Host: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
TNF Receptor Superfamily, Member 6 (FAS) protein (His tag)FAS Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
TNF Receptor Superfamily, Member 6 (FAS) (AA 17-173) protein (His tag)FAS Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
TNF Receptor Superfamily, Member 6 (FAS) (AA 1-335) protein (GST tag)FAS Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
TNF Receptor Superfamily, Member 6 (FAS) (AA 20-119) protein (GST tag)FAS Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
TNF Receptor Superfamily, Member 6 (FAS) (Active) protein (His tag)FAS Origin: Rat Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
TNF Receptor Superfamily, Member 6 (FAS) (Active) protein (His tag)FAS Origin: Mouse Host: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant Human Fas Receptor remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Human Fas Receptor should be stable up to 1 week at 4°C or up to 2 months at -20°C.
- Expiry Date
- 6 months
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- Target
- FAS (TNF Receptor Superfamily, Member 6 (FAS))
- Alternative Name
- Fas Receptor (FAS Products)
- Synonyms
- ALPS1A Protein, APO-1 Protein, APT1 Protein, CD95 Protein, FAS1 Protein, FASTM Protein, TNFRSF6 Protein, AI196731 Protein, APO1 Protein, TNFR6 Protein, Tnfrsf6 Protein, lpr Protein, Fas cell surface death receptor Protein, Fas (TNF receptor superfamily member 6) Protein, FAS Protein, Fas Protein, fas Protein
- Background
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Fas Receptor and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL.
Synonyms: soluble Fas receptor (sFasR), TNFRSF6, CD95, Apo I, Fas Antigen - Molecular Weight
- 17-29 kDa, observed by reducing SDS-PAGE.
- NCBI Accession
- NP_000034
- Pathways
- p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
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