RAF1 Protein (AA 2061-2302) (GST tag)

Catalog No. ABIN935464

Product Details

Target: RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))

Protein Type: Recombinant

Protein Characteristics: AA 2061-2302

Origin: Hepatitis C Virus (HCV)

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This RAF1 protein is labelled with GST tag.

Application: ELISA, Western Blotting (WB)

Characteristics: Purified recombinant Hepatitis C Virus NS5 protein
Expression System: E.coli

Purification: Proprietary chromatographic technique

Purity: > 95 % pure

Application Details

Application Notes: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 25 mM tris-HCl, pH -8, with 1.5 M urea, 0.2 % Triton-X and 52 % glycerol.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: RT/-20 °C

Target Details

Target: RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))

Alternative Name: NS5 (RAF1 Products)

Synonyms: CRAF Protein, NS5 Protein, Raf-1 Protein, c-Raf Protein, c-raf Protein, craf Protein, raf1 Protein, RAF1 Protein, 6430402F14Rik Protein, AA990557 Protein, BB129353 Protein, Craf1 Protein, D830050J10Rik Protein, v-Raf Protein, raf Protein, cRaf Protein, Raf-1 proto-oncogene, serine/threonine kinase Protein, Raf-1 proto-oncogene, serine/threonine kinase a Protein, v-raf-leukemia viral oncogene 1 Protein, Raf-1 proto-oncogene, serine/threonine kinase S homeolog Protein, RAF1 Protein, Raf1 Protein, raf1a Protein, raf1 Protein, raf1.S Protein

Background: HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae. HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6).
Alternative Names: HCV Recombinant protein, Hep C protein, Hepatitis C protein, HCV NS5 protein, HCV protein

Pathways: MAPK Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Stem Cell Maintenance, Hepatitis C, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling, BCR Signaling