PIGR Protein (His tag)

Catalog No. ABIN2566874

Product Details

Target: PIGR (Polymeric Immunoglobulin Receptor (PIGR))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This PIGR protein is labelled with His tag.

Application: Western Blotting (WB), ELISA

Characteristics:

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human PIGR at 2 μg/mL, the concentration of human IgM that produces 50 % of the optimal binding response is appoximately 20-200 ng/mL.

Purity: >98 % as determined by SDS-PAGE.

Application Details

Application Notes: This recombinant protein can be used for WB, ELISA. For research use only.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -80 °C,-20 °C

Storage Comment: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Target Details

Target: PIGR (Polymeric Immunoglobulin Receptor (PIGR))

Alternative Name: Poly Ig Receptor (PIGR Products)

Synonyms: DKFZp469G1013 Protein, RNPIGR2 Protein, pIgA-R Protein, polymeric immunoglobulin receptor Protein, PIGR Protein, Pigr Protein

Background: Polymeric immunoglobulin receptor (PIGR) is also known as Poly-Ig receptor, which can be cleaved into membrane secretory component (SC). PIGR is a type I transmembrane glycoprotein or a member of the immunoglobulin superfamily, and is synthesized by secretory epithelial cells and delivered to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA ) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

Molecular Weight: 68.7 kDa

Gene ID: 5284

UniProt: P01833