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CCL21 Protein

CCL21 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, STD, PI Active
Catalog No. ABIN2714242
  • Target See all CCL21 Proteins
    CCL21 (Chemokine (C-C Motif) Ligand 21 (CCL21))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 9
    • 7
    • 2
    • 1
    • 1
    Human
    Source
    • 14
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Application
    Functional Studies (Func), Antibody Production (AbP), Standard (STD), Protein Interaction (PI)
    Specificity
    Optimal preservation of protein structure, post-translational modifications and functions.
    Characteristics
    • Recombinant human 6CKine / CCL21 protein expressed in E. coli.
    • Produced with end-sequenced ORF clone
    • Tested for bioactivity.
    Purity
    > 95 % as determined by SDS-PAGE and Coomassie blue staining
    Endotoxin Level
    Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
    Biological Activity Comment
    Determined by its ability to chemoattract total lymphocyte population using a concentration range of 10.0-100.0 ng/ml.
    Top Product
    Discover our top product CCL21 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Protein-protein interaction
    In vitro biochemical assays and cell-based functional assays
    Restrictions
    For Research Use only
  • Buffer
    Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2
    Handling Advice
    Resuspend the protein in the desired concentration in proper buffer
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    CCL21 (Chemokine (C-C Motif) Ligand 21 (CCL21))
    Alternative Name
    6ckine,ccl21 (CCL21 Products)
    Synonyms
    6Ckine Protein, CKb9 Protein, ECL Protein, SCYA21 Protein, SLC Protein, TCA4 Protein, ccl21 Protein, Ccl21b Protein, C-C motif chemokine ligand 21 Protein, C-C motif chemokine 21 Protein, CCL21 Protein, ccl21 Protein, Ccl21 Protein
    Background
    Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. [UniProtKB/Swiss-Prot Function]
    Molecular Weight
    12.2 kDa
    NCBI Accession
    NP_002980
    Pathways
    Regulation of Actin Filament Polymerization
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