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FGF2 Protein (AA 131-288)

FGF2 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % (SDS-PAGE) SDS
Catalog No. ABIN2745670
  • Target See all FGF2 Proteins
    FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 131-288
    Origin
    • 17
    • 8
    • 7
    • 6
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 34
    • 9
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Application
    SDS-PAGE (SDS)
    Cross-Reactivity
    Human
    Characteristics
    Human FGF-2 (aa 131-288) is untagged.
    Purity
    >95 % (SDS-PAGE)
    Endotoxin Level
    <0.1EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product FGF2 Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute with 100 μL sterile water.
    Concentration
    Lot specific
    Buffer
    Lyophilized. Contains PBS + 0.1 mM DTT.
    Preservative
    Dithiothreitol (DTT)
    Precaution of Use
    This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    Expiry Date
    6 months
  • Target
    FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))
    Alternative Name
    FGF-2 (FGF2 Products)
    Synonyms
    BFGF Protein, FGF-2 Protein, FGFB Protein, HBGF-2 Protein, Fgf-2 Protein, Fgfb Protein, bFGF Protein, fibroblast growth factor 2 Protein, fibroblast growth factor 2 (basic) Protein, FGF2 Protein, Fgf2 Protein, fgf2 Protein
    Background
    FGF-2 (Basic fibroblast growth factor) belongs to the FGF superfamily that is made up of 22 different fibroblast growth factor genes. FGF-2 and FGF-1 (acidic FGF) are unique in that they do not follow the conventional signal sequence for secretion. FGF-2 is found in five isoforms via alternative initiation of translation. Signaling of FGF-2 occurs through the high-affinity tyrosine kinase receptors FGFR1-4. FGF-2 is a potent wide-spectrum mitogen whose overexpression is associated with immortalization and unregulated cell proliferation in many tumors. FGF-2 functions in angiogenesis, cell survival, tissue repair, embryonic development and inflammation. FGF-2 is widely used to maintain the self-renewal of human embryonic stem cells (ESCs) and to induce pluripotent stem cells. FGF-2 is an established neurogenic factor for proliferation and differentiation of multipotent neural stem cells both during development and in the adult mouse brain as well.
    Molecular Weight
    18 kDa
    UniProt
    P09038
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, C21-Steroid Hormone Metabolic Process, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Protein targeting to Nucleus, S100 Proteins
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