DLL4 Protein (AA 1-529, Extracellular Domain) (Fc Tag)
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- Target See all DLL4 Proteins
- DLL4 (delta-Like 4 (DLL4))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 1-529, Extracellular Domain
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This DLL4 protein is labelled with Fc Tag.
- Application
- SDS-PAGE (SDS)
- Specificity
- Interacts with human Notch1 (as confirmed by flow cytometry).
- Cross-Reactivity
- Human
- Characteristics
- Signal peptide and extracellular domain of human DLL4 (aa 1-529) are fused at the C-terminus to the Fc portion of human IgG1.
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product DLL4 Protein
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delta-Like 4 (DLL4) (AA 27-524) protein (His-Avi Tag,Biotin)
DLL4 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
delta-Like 4 (DLL4) (AA 27-524) protein (Fc Tag)DLL4 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
delta-Like 4 (DLL4) (AA 558-685) protein (His-IF2DI Tag)DLL4 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
delta-Like 4 (DLL4) (AA 123-221) protein (GST tag)DLL4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
delta-Like 4 (DLL4) (Active) protein (His tag)DLL4 Origin: Mouse Host: HEK-293 Cells Recombinant > 96 % as determined by SDS-PAGE Active
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Inhibits adipogenesis of 3T3L-1 cells and mesenchymal stem cells (MSCs). Induces the Notch target gene HES-1 when coated on a plate at 1μg/ml.
- Restrictions
- For Research Use only
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- Format
- Solid
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS + 0.5 % Trehalose.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Expiry Date
- 6 months
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- Target
- DLL4 (delta-Like 4 (DLL4))
- Alternative Name
- DLL4 (DLL4 Products)
- Synonyms
- hdelta2 Protein, Delta4 Protein, si:ch211-244p18.5 Protein, zgc:136596 Protein, delta like canonical Notch ligand 4 Protein, delta-like 4 (Drosophila) Protein, DLL4 Protein, Dll4 Protein, dll4 Protein
- Background
- The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
- Molecular Weight
- ~80kDa (SDS-PAGE)
- UniProt
- Q9NR61
- Pathways
- Notch Signaling
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