PPARG Protein (AA 1-477) (His-SUMO Tag)
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- Target See all PPARG Proteins
- PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-477
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This PPARG protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MTMVDTEMPF WPTNFGISSV DLSVMEDHSH SFDIKPFTTV DFSSISTPHY EDIPFTRTDP VVADYKYDLK LQEYQSAIKV EPASPPYYSE KTQLYNKPHE EPSNSLMAIE CRVCGDKASG FHYGVHACEG CKGFFRRTIR LKLIYDRCDL NCRIHKKSRN KCQYCRFQKC LAVGMSHNAI RFGRMPQAEK EKLLAEISSD IDQLNPESAD LRALAKHLYD SYIKSFPLTK AKARAILTGK TTDKSPFVIY DMNSLMMGED KIKFKHITPL QEQSKEVAIR IFQGCQFRSV EAVQEITEYA KSIPGFVNLD LNDQVTLLKY GVHEIIYTML ASLMNKDGVL ISEGQGFMTR EFLKSLRKPF GDFMEPKFEF AVKFNALELD DSDLAIFIAV IILSGDRPGL LNVKPIEDIQ DNLLQALELQ LKLNHPESSQ LFAKLLQKMT DLRQIVTEHV QLLQVIKKTE TDMSLHPLLQ EIYKDLY
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product PPARG Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))
- Alternative Name
- PPARG (PPARG Products)
- Synonyms
- PPAR gamma Protein, PPARg2 Protein, PPARG Protein, Nr1c3 Protein, PPAR-gamma Protein, PPAR-gamma2 Protein, PPARgamma Protein, PPARgamma2 Protein, NR1C3 Protein, CIMT1 Protein, GLM1 Protein, PPARG1 Protein, PPARG2 Protein, xPPAR-gamma Protein, PPAR-GAMMA Protein, PPARGAMMA Protein, peroxisome proliferator-activated receptor gamma Protein, peroxisome proliferator activated receptor gamma Protein, peroxisome proliferator activated receptor gamma L homeolog Protein, PPARG Protein, Pparg Protein, pparg.L Protein
- Background
- Nuclear receptor that binds peroxisome proliferators such as hypolipidic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elents (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels .
- Molecular Weight
- 70.6 kDa
- UniProt
- P37231
- Pathways
- MAPK Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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