PRNP Protein (AA 29-231) (His tag)
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- Target See all PRNP Proteins
- PRNP (Prion Protein (PRNP))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 29-231
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Origin
- Rat
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This PRNP protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- GGWNTGGSRY PGQGSPGGNR YPPQSGGTWG QPHGGGWGQP HGGGWGQPHG GGWGQPHGGG WSQGGGTHNQ WNKPSKPKTN LKHVAGAAAA GAVVGGLGGY MLGSAMSRPM LHFGNDWEDR YYRENMYRYP NQVYYRPVDQ YSNQNNFVHD CVNITIKQHT VTTTTKGENF TETDVKMMER VVEQMCVTQY QKESQAYYDG RRS
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product PRNP Protein
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Prion Protein (PRNP) (AA 23-230) protein (Fc Tag)
PRNP Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Prion Protein (PRNP) (AA 23-230) protein (Fc Tag)PRNP Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Prion Protein (PRNP) (AA 1-253) protein (GST tag)PRNP Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Prion Protein (PRNP) (AA 1-73) protein (Strep Tag)Crystallography grade PRNP Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB
Prion Protein (PRNP) proteinPRNP Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % ELISA, SDS, WB, IP
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- PRNP (Prion Protein (PRNP))
- Alternative Name
- PRIO (PRNP Products)
- Synonyms
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ASCR Protein, AltPrP Protein, CD230 Protein, CJD Protein, GSS Protein, KURU Protein, PRIP Protein, PrP Protein, PrP27-30 Protein, PrP33-35C Protein, PrPc Protein, p27-30 Protein, Prn Protein, Prn-p Protein, prp Protein, cjd Protein, prion Protein, prp(c) Protein, MGC84114 Protein, PRP Protein, PRPC Protein, Prp Protein, SIP Protein, PRNP Protein, AA960666 Protein, AI325101 Protein, PrP
Protein, PrPC Protein, PrPSc Protein, Prn-i Protein, Sinc Protein, prP27-30 Protein, prP33-35C Protein, PrP-1 Protein, PrP1 Protein, prnprs1 Protein, stPrP-1 Protein, zgc:123004 Protein, prion protein Protein, prion protein S homeolog Protein, prion protein b Protein, PRNP Protein, Prnp Protein, prnp.S Protein, prnpb Protein - Background
- May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains .
- Molecular Weight
- 26.34 kDa
- UniProt
- P13852
- Pathways
- Transition Metal Ion Homeostasis, Activated T Cell Proliferation
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