TIMM8A/DDP Protein (AA 1-97) (His tag)

Catalog No. ABIN5853449

Product Details

Target: TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))

Protein Type: Recombinant

Protein Characteristics: AA 1-97

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This TIMM8A/DDP protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MGSSHHHHHH SSGLVPRGSH MGSMDSSSSS SAAGLGAVDP QLQHFIEVET QKQRFQQLVH QMTELCWEKC MDKPGPKLDS RAEACFVNCV ERFIDTSQFI LNRLEQTQKS KPVFSESLSD

Purity: > 90 % by SDS - PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.15M NaCl, 30 % glycerol, 1  mM DTT

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Target Details

Target: TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))

Alternative Name: TIMM8A (TIMM8A Products)

Synonyms: TIMM8A Protein, ddp Protein, tim8a Protein, timm8a Protein, DDP Protein, DDP1 Protein, DFN1 Protein, MTS Protein, TIM8 Protein, im:6896085 Protein, zgc:100916 Protein, Ddp1 Protein, Timm8a Protein, DXHXS1274E Protein, Fci-12 Protein, Tim8a Protein, translocase of inner mitochondrial membrane 8 homolog A (yeast) Protein, translocase of inner mitochondrial membrane 8A Protein, translocase of inner mitochondrial membrane 8 homolog A1 (yeast) Protein, translocase of inner mitochondrial membrane 8A1 Protein, TIMM8A Protein, timm8a Protein, Timm8a1 Protein

Background: TIMM8A is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome, an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Recombinant human TIMM8A proten, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molecular Weight: 13.4kDa (120aa) confirmed by MALDI-TOF

NCBI Accession: NP_004076

UniProt: O60220