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TIMM8A/DDP Protein (AA 1-97) (His tag)

TIMM8A Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
Catalog No. ABIN5853449
  • Target See all TIMM8A/DDP (TIMM8A) Proteins
    TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 1-97
    Origin
    • 3
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 4
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This TIMM8A/DDP protein is labelled with His tag.
    Application
    SDS-PAGE (SDS)
    Sequence
    MGSSHHHHHH SSGLVPRGSH MGSMDSSSSS SAAGLGAVDP QLQHFIEVET QKQRFQQLVH QMTELCWEKC MDKPGPKLDS RAEACFVNCV ERFIDTSQFI LNRLEQTQKS KPVFSESLSD
    Purity
    > 90 % by SDS - PAGE
    Top Product
    Discover our top product TIMM8A Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.15M NaCl, 30 % glycerol, 1  mM DTT
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
  • Target
    TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))
    Alternative Name
    TIMM8A (TIMM8A Products)
    Synonyms
    TIMM8A Protein, ddp Protein, tim8a Protein, timm8a Protein, DDP Protein, DDP1 Protein, DFN1 Protein, MTS Protein, TIM8 Protein, im:6896085 Protein, zgc:100916 Protein, Ddp1 Protein, Timm8a Protein, DXHXS1274E Protein, Fci-12 Protein, Tim8a Protein, translocase of inner mitochondrial membrane 8 homolog A (yeast) Protein, translocase of inner mitochondrial membrane 8A Protein, translocase of inner mitochondrial membrane 8 homolog A1 (yeast) Protein, translocase of inner mitochondrial membrane 8A1 Protein, TIMM8A Protein, timm8a Protein, Timm8a1 Protein
    Background
    TIMM8A is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome, an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Recombinant human TIMM8A proten, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
    Molecular Weight
    13.4kDa (120aa) confirmed by MALDI-TOF
    NCBI Accession
    NP_004076
    UniProt
    O60220
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