CRTAM Protein (AA 18-287) (His tag)
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- Target See all CRTAM Proteins
- CRTAM (Cytotoxic and Regulatory T Cell Molecule (CRTAM))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 18-287
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Origin
- Human
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Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This CRTAM protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- SLTNHTETIT VEEGQTLTLK CVTSLRKNSS LQWLTPSGFT IFLNEYPALK NSKYQLLHHS ANQLSITVPN VTLQDEGVYK CLHYSDSVST KEVKVIVLAT PFKPILEASV IRKQNGEEHV VLMCSTMRSK PPPQITWLLG NSMEVSGGTL HEFETDGKKC NTTSTLIIHT YGKNSTVDCI IRHRGLQGRK LVAPFRFEDL VTDEETASDA LERNSLSSQD PQQPTSTVSV TEDSSTSEID KEEKEQTTQD PDLTTEANPQ YLGLARKKSG LEHHHHHH
- Purity
- > 90 % by SDS - PAGE
- Endotoxin Level
- < 1.0 EU per 1 microgram of protein (determined by LAL method)
- Top Product
- Discover our top product CRTAM Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid. In Phosphate Buffered Saline ( pH 7.4) containing 10 % glycerol.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- CRTAM (Cytotoxic and Regulatory T Cell Molecule (CRTAM))
- Alternative Name
- Cytotoxic and regulatory T-cell molecule (CRTAM Products)
- Synonyms
- TAD Protein, cTADS Protein, MGC82176 Protein, CRTAM Protein, CD355 Protein, cytotoxic and regulatory T-cell molecule Protein, cytotoxic and regulatory T-cell molecule L homeolog Protein, cytotoxic and regulatory T cell molecule Protein, CRTAM Protein, crtam.L Protein, Crtam Protein
- Background
- CRTAM, also known as cytotoxic and regulatory T-cell molecule, is a member of the immunoglobulin superfamily that complies with the structural characteristics of the JAM family of proteins and is phylogenetically more closely related to nectin-like proteins. It is a molecule involved in epithelial cell adhesion. This protein interacts with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Recombinant human CRTAM, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
- Molecular Weight
- 31.0kDa (278aa) 40-57KDa (SDS-PAGE under reducing conditions.)
- NCBI Accession
- NP_062550
- UniProt
- O95727
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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