MAP2K6 Protein (AA 53-314) (His tag)
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- Target See all MAP2K6 Proteins
- MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 53-314
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This MAP2K6 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MLEPIMELGR GAYGVVEKMR HVPSGQIMAV KRIRATVNSQ EQKRLLMDLD ISMRTVDCPF TVTFYGALFR EGDVWICMEL MDTSLDKFYK QVIDKGQTIP EDILGKIAVS IVKALEHLHS KLSVIHRDVK PSNVLINALG QVKMCDFGIS GYLVDEVAKE IDAGCKPYMA PERINPELNQ KGYSVKSDIW SLGITMIELA ILRFPYDSWG TPFQQLKQVV EEPSPQLPAD KFSAEFVDFT SQCLKKNSKE RPTYPELMQH PFF
- Purity
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product MAP2K6 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Denatured
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- Liquid, In 20 mM Tris-HCl ( pH 8.0) containing 10 % glycerol
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles
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- Target
- MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))
- Alternative Name
- MAP2K6 (MAP2K6 Products)
- Synonyms
- MAPKK6 Protein, MEK6 Protein, MKK6 Protein, PRKMK6 Protein, SAPKK-3 Protein, SAPKK3 Protein, Mkk6 Protein, Prkmk6 Protein, MKK3 Protein, map2k3 Protein, zMKK3 Protein, map2k6 Protein, mitogen-activated protein kinase kinase 6 Protein, mitogen-activated protein kinase kinase 6 L homeolog Protein, MAP2K6 Protein, Map2k6 Protein, map2k6 Protein, map2k6.L Protein
- Background
- MAP2K6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, MAP2K6 is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. Recombinant human MAP2K6, fused to His-tag at N-terminus, was expressed in E.coli.
- Molecular Weight
- 32.0 kDa (383aa)
- NCBI Accession
- NP_002749
- UniProt
- P52564
- Pathways
- MAPK Signaling, TLR Signaling, Activation of Innate immune Response, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades
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