CNDP1 Protein (His tag)
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- Target See all CNDP1 Proteins
- CNDP1 (Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CNDP1 protein is labelled with His tag.
- Purpose
- Recombinant Mouse CNDP1 Protein (His Tag)(Active)
- Sequence
- Met 1-Tyr 492
- Characteristics
- A DNA sequence encoding the mouse CNDP1 (Q8BUG2) (Met 1-Tyr 492) was expressed, with an N-terminal signal peptide and a C-terminal polyhistidine tag.
- Purity
- > 93 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to cleave carnosine (ß-Ala-L-His)in a two-step assay.The specific activity is > 250 pmoles/min/μg.
- Top Product
- Discover our top product CNDP1 Protein
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Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) (AA 28-147) protein (His-IF2DI Tag)
CNDP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) (AA 1-507) protein (GST tag)CNDP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) (AA 1-492) protein (His tag)CNDP1 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95 % by SDS - PAGE SDS
Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) (AA 27-507) (Active) protein (His tag)CNDP1 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95 % by SDS - PAGE SDS Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- CNDP1 (Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1))
- Alternative Name
- CNDP1 (CNDP1 Products)
- Synonyms
- cn1 Protein, cpgl2 Protein, CNDP1 Protein, CN1 Protein, CPGL2 Protein, HsT2308 Protein, AI746433 Protein, Cn1 Protein, carnosine dipeptidase 1 (metallopeptidase M20 family) L homeolog Protein, carnosine dipeptidase 1 Protein, carnosine dipeptidase 1 (metallopeptidase M20 family) Protein, cndp1.L Protein, CNDP1 Protein, cndp1 Protein, Cndp1 Protein
- Background
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Background: CNDP1, also known as carnosine dipeptidase 1, glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), is a member of the M20 metalloprotease family. The CNDP1 gene contains trinucleotide (CTG) repeat length polymorphism in the coding region, which has been demonstrated to be associated with susceptibility to developing diabetic nephropathy, for carnosine protection against the adverse effects of high glucose levels on renal cells. In humans, CNDP1 is secreted from the liver into the serum. In other mammals, including rodents, CNDP1 is expressed exclusively within the kidney and lacks a signal peptide. CNDP1 protein is a secreted homodimeric dipeptidase that specifically hydrolyzes L-carnosine (β-alanyl-L-histidine), and is identified as human carnosinase expressed in the brain. CNDP1 has been associated with diabetic nephropathy in Europeans and European Americans, but not African-Americans. It was identified and confirmed as a risk factor, were cross-sectional and mostly in patients with type 2 diabetes. The polymorphisms of CNDP1 can be excluded as a risk factor for nephropathy in type 1 diabetes. In addition, CNDP1 is also suggested to be implicated in the actions of neuroprotection and neurotransmiting.
Synonym: AI746433;Cn1
- Molecular Weight
- 56.5 kDa
- UniProt
- Q8BUG2
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