EPH Receptor A3 Protein (EPHA3) (His tag)

Catalog No. ABIN7195523

Product Details

Target: EPH Receptor A3 (EPHA3)

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This EPH Receptor A3 protein is labelled with His tag.

Purpose: Recombinant Mouse EphA3 Protein (His Tag)(Active)

Sequence: Met1-His541

Characteristics: A DNA sequence encoding the mouse EPHA3 (NP_034270.1) (Met1-His541) was expressed with a C-terminal polyhistidine tag.

Purity: > 95 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: 1. Measured by its binding ability in a functional ELISA.2. Immobilized mouse EPHA3-His at 10 μg/mL (100 μL/well) can bind mouse EFNA5-Fc . The EC50 of mouse EFNA5-Fc is 4.9-11.4ng/mL.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: EPH Receptor A3 (EPHA3)

Alternative Name: EphA3 (EPHA3 Products)

Synonyms: EK4 Protein, ETK Protein, ETK1 Protein, HEK Protein, HEK4 Protein, TYRO4 Protein, EPHA3 Protein, AW492086 Protein, Cek4 Protein, End3 Protein, Hek Protein, Hek4 Protein, Mek4 Protein, Tyro4 Protein, CEK4 Protein, EPH receptor A3 Protein, ephrin type-A receptor 3 Protein, Eph receptor A3 Protein, EPHA3 Protein, LOC100439679 Protein, Epha3 Protein

Background:

Background: EPHA3 gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EPHA3 gene encodes a protein that binds ephrin-A ligands. EPHA3 is involved in the retinotectal mapping of neurons. It may also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: AW492086;Cek4;End3;ETK1;Hek;Hek4;Mek4;Tyro4

Molecular Weight: 60.2 kDa

NCBI Accession: NP_796047

Pathways: RTK Signaling, Regulation of Cell Size