Haptoglobin Protein (HP) (AA 19-160, AA 162-406) (His tag)

Catalog No. ABIN7318556

Product Details

Target: Haptoglobin (HP)

Protein Type: Recombinant

Protein Characteristics: AA 162-406, AA 19-160

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This Haptoglobin protein is labelled with His tag.

Purpose: Recombinant Human Haptoglobin/Zonulin Protein (aa 19-160&aa 162-406, His Tag)

Sequence: Val19-Gln160&Ile162-Asn406

Characteristics: Recombinant Human Haptoglobin/Zonulin is produced by our Mammalian expression system and the target gene encoding Val19-Gln160(alpha chain)&Ile162-Asn406(beta chain) is expressed with a 6His tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, 1 mM DTT, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Haptoglobin (HP)

Alternative Name: Haptoglobin/Zonulin (HP Products)

Synonyms: HP Protein, wu:fb64e01 Protein, BP Protein, HP2ALPHA2 Protein, HPA1S Protein, HP-1 Protein, HPR Protein, Zonulin Protein, haptoglobin Protein, haptoglobin-like Protein, HP Protein, hp Protein, Hp Protein, LOC479668 Protein, LOC101102413 Protein

Background:

Background: Haptoglobin(HP) is a secreted protein which is a member of the peptidase S1 family of serine proteases. As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial, Antioxidant has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

Synonym: Haptoglobin,Zonulin,HP

Molecular Weight: 15.9&28.3

UniProt: P00738

Pathways: Transition Metal Ion Homeostasis