IL-2 Protein (His tag)
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- Target See all IL-2 (IL2) Proteins
- IL-2 (IL2) (Interleukin 2 (IL2))
- Protein Type
- Recombinant
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Origin
- Rat
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Source
- Human Cells
- Purification tag / Conjugate
- This IL-2 protein is labelled with His tag.
- Purpose
- Recombinant Rat Interleukin-2/IL-2 Protein (His Tag)
- Sequence
- Ala21-Gln155
- Characteristics
- Recombinant Rat Interleukin-2 is produced by our Mammalian expression system and the target gene encoding Ala21-Gln155 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product IL2 Protein
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 5 mM NaH2PO4, 5 mM Citric acid, 150 mM NaCl, pH 4.0.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- IL-2 (IL2) (Interleukin 2 (IL2))
- Alternative Name
- Interleukin-2/IL-2 (IL2 Products)
- Synonyms
- IL2 Protein, IL-2 Protein, il2 Protein, TCGF Protein, lymphokine Protein, Il-2 Protein, POIL2 Protein, interleukin 2 Protein, interleukin-15 Protein, IL2 Protein, il2 Protein, LOC100303688 Protein, Il2 Protein
- Background
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Background: Interleukin-2(IL-2)is a O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. Mature rat IL-2 shares 66 % and 73 % amino acid sequence identity with human and mouse IL-2,respectively. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.
Synonym: Interleukin-2, IL-2, T-cell growth factor, TCGF, Aldesleukin, IL2
- Molecular Weight
- 16.3 kDa
- UniProt
- P17108
- Pathways
- JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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