RAB7A Protein (His tag)

Catalog No. ABIN7321067

Product Details

Target: RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))

Protein Type: Recombinant

Origin: Rat

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This RAB7A protein is labelled with His tag.

Purpose: Recombinant Rat RAB7A/Rab-7a Protein (His Tag)

Sequence: Met1-Cys207

Characteristics: A DNA sequence encoding the rat Rab7a (NP_076440.1) (Met1-Cys207) was expressed with a polyhistidine tag at the N-terminus.

Purity: > 90 % as determined by SDS-PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, 10 % glycerol

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))

Alternative Name: RAB7A/Rab-7a (RAB7A Products)

Synonyms: RAB5 Protein, PRO2706 Protein, RAB7 Protein, Rab7 Protein, rab7 Protein, pro2706 Protein, RAB7A Protein, LOC100231734 Protein, ARABIDOPSIS RAB GTPASE HOMOLOG G2 Protein, ATRAB7A Protein, ATRABG2 Protein, F7D8.20 Protein, F7D8_20 Protein, RAB GTPase homolog 7A Protein, DDBDRAFT_0190210 Protein, DDBDRAFT_0191507 Protein, DDB_0190210 Protein, DDB_0191507 Protein, Rab7a Protein, rab-7 Protein, zgc:64058 Protein, RAB5A, member RAS oncogene family Protein, RAB7A, member RAS oncogene family Protein, RAB7A, member RAS oncogene family L homeolog Protein, rab7A protein Protein, RAB GTPase homolog 7A Protein, Rab GTPase Protein, ras-related protein rab-7a Protein, RAB7, member RAS oncogene family Protein, RAB5A Protein, RAB7A Protein, Rab7a Protein, rab7a.L Protein, rab7a Protein, rab7A Protein, Rab7 Protein, rab7 Protein

Background:

Background: RAB7A is a ubiquitous small GTPase, which controls transport to late endocytic compartments. Silencing or overexpression of wild type RAB7A changed the soluble/insoluble rate of peripherin indicating that RAB7A is important for peripherin organization and function. In addition, disease-causing RAB7A mutant proteins bind more strongly to peripherin and their expression causes a significant increase in the amount of soluble peripherin. The altered interaction between disease-causing RAB7A mutants and peripherin could play an important role in CMT2B neuropathy.

Synonym: Rab7

Molecular Weight: 25.7 kDa

NCBI Accession: NP_076440

Pathways: EGFR Signaling Pathway, Maintenance of Protein Location, SARS-CoV-2 Protein Interactome