SLAMF6 Protein (AA 28-225) (His tag)
-
- Target See all SLAMF6 Proteins
- SLAMF6 (SLAM Family Member 6 (SLAMF6))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 28-225
-
Origin
- Human
-
Source
- Human Cells
- Purification tag / Conjugate
- This SLAMF6 protein is labelled with His tag.
- Purpose
- Recombinant Human SLAMF6/Ly108 Protein (aa 28-225, His Tag)(Active)
- Sequence
- Leu28-Lys225
- Characteristics
- Recombinant Human SLAM Family Member 6 is produced by our Mammalian expression system and the target gene encoding Leu28-Lys225 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to induce IFN-γ secretion by PBMC cells.
- Top Product
- Discover our top product SLAMF6 Protein
-
SLAM Family Member 6 (SLAMF6) (AA 22-226) protein (Fc Tag)
SLAMF6 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
SLAM Family Member 6 (SLAMF6) (AA 22-226) protein (His-Avi Tag)SLAMF6 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
SLAM Family Member 6 (SLAMF6) (AA 20-225) protein (His tag)SLAMF6 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
SLAM Family Member 6 (SLAMF6) protein (mFc-His Tag)SLAMF6 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
SLAM Family Member 6 (SLAMF6) (AA 1-271) protein (GST tag)SLAMF6 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
SLAM Family Member 6 (SLAMF6) (Active) protein (His tag)SLAMF6 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- Target
- SLAMF6 (SLAM Family Member 6 (SLAMF6))
- Alternative Name
- SLAMF6/Ly108 (SLAMF6 Products)
- Synonyms
- SLAMF6 Protein, CD352 Protein, KALI Protein, KALIb Protein, Ly108 Protein, NTB-A Protein, NTBA Protein, SF2000 Protein, KAL1 Protein, KAL1b Protein, RGD1561848 Protein, SLAM family member 6 Protein, SLAMF6 Protein, Slamf6 Protein
- Background
-
Background: SLAM Family Member 6 (SLAMF6) is a 60 kD single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6/ NTB-A contains a 205 amino acid extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain, a 21 amino acid transmembrane segment and an 84 amino acid cytoplasmic domain, with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a homodimer. SLAMF6 can interact with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Phosphorylation-dependent NTB-A association with SAP is required for full production of IFN-γ by NK cells and independent of EAT-2 binding. It Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. On B cells, NTB-A modulates immunoglobulin class switching and the balance between tolerance and autoimmunity.
Synonym: SLAM Family Member 6, Activating NK Receptor, NK-T-B-Antigen, NTB-A, CD352, SLAMF6, KALI, Ly108, NTBA, SF2000
- Molecular Weight
- 23.4 kDa
- UniProt
- Q96DU3
-
