SMPDL3A Protein (His tag)

Catalog No. ABIN7320020

Product Details

Target: SMPDL3A (Sphingomyelin phosphodiesterase, Acid-Like 3A (SMPDL3A))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This SMPDL3A protein is labelled with His tag.

Purpose: Recombinant Mouse SMPDL3A Protein (His Tag)

Sequence: Met1-Leu445

Characteristics: A DNA sequence encoding the mouse Smpdl3a (NP_065586.3) (Met1-Leu445) was expressed with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SMPDL3A (Sphingomyelin phosphodiesterase, Acid-Like 3A (SMPDL3A))

Alternative Name: SMPDL3A (SMPDL3A Products)

Synonyms: ASM3A Protein, ASML3a Protein, yR36GH4.1 Protein, 0610010C24Rik Protein, AI529588 Protein, ASML3 Protein, ASML3A Protein, sphingomyelin phosphodiesterase acid like 3A Protein, sphingomyelin phosphodiesterase, acid-like 3A Protein, SMPDL3A Protein, Smpdl3a Protein

Background:

Background: SMPDL3A gene is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR α and LXRβ function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems, revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases. The LXR genome landscape has been investigated in murine macrophages but not in human THP-1 cells, which represent one of the frequently used monocyte/macrophage cell systems to study immune responses.

Synonym: 0610010C24Rik,AI529588,ASM3A,ASML3,ASML3A

Molecular Weight: 49.1 kDa

NCBI Accession: NP_065586