Osteoactivin Protein (GPNMB) (AA 23-502) (His tag)
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- Target See all Osteoactivin (GPNMB) Proteins
- Osteoactivin (GPNMB)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 23-502
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Osteoactivin protein is labelled with His tag.
- Purpose
- Mouse Osteoactivin/GPNMB Protein
- Sequence
- Lys23-Asn502
- Characteristics
- Recombinant Mouse Osteoactivin/GPNMB Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Lys23-Asn502.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product GPNMB Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Osteoactivin (GPNMB)
- Alternative Name
- Osteoactivin (GPNMB Products)
- Synonyms
- HGFIN Protein, NMB Protein, DC-HIL Protein, Dchil Protein, ipd Protein, glycoprotein nmb Protein, glycoprotein (transmembrane) nmb Protein, glycoprotein nmb L homeolog Protein, Gpnmb Protein, GPNMB Protein, gpnmb.L Protein
- Background
- GPNMB is highly expressed in macrophages and microglia, which are cells involved with innate immune response in the periphery and the brain, respectively. Some studies have shown increased levels of GPNMB in pro-inflammatory conditions, such as LPS treatment, and in pathological conditions, such as neurodegenerative diseases and cancer.
- Molecular Weight
- 54.7 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Tris-Bis PAGE result.
- NCBI Accession
- NP_444340
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