ITGAV/ITGB5 Protein (His tag)
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- Target See all ITGAV/ITGB5 products
- ITGAV/ITGB5 (Integrin alpha V / beta 5 (ITGAV/ITGB5))
- Protein Type
- Recombinant
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Origin
- Rat
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ITGAV/ITGB5 protein is labelled with His tag.
- Purpose
- Rat Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free
- Sequence
- Phe 31 - Pro 988 (ITGAM) & Leu 25 - Asn 719 (ITGB5)
- Characteristics
- Rat ITGAV&ITGB5 Heterodimer, His Tag&Tag Free is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 988 (ITGAM) & Leu 25 - Asn 719 (ITGB5) (Accession # NP_001385621.1 (ITGAM) & NP_671480.2 (ITGB5).
- Purity
- 90,00 %
- Endotoxin Level
- 1.0 EU per μg
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Integrin alpha V / beta 5 (ITGAV/ITGB5) (AA 31-992) protein (His-Avi Tag,Biotin)
ITGAV/ITGB5 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin alpha V / beta 5 (ITGAV/ITGB5) (AA 31-992) protein (His tag,AVI tag,Biotin)ITGAV/ITGB5 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Integrin alpha V / beta 5 (ITGAV/ITGB5) (AA 31-992) (Active) protein (His tag)ITGAV/ITGB5 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
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- Comment
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Rat ITGAV&ITGB5 Heterodimer, His Tag&Tag Free, has a calculated MW of 112.3 kDa (ITGAV) & 81.6 kDa (ITGB3). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB3 contains no tag but a basic tail at the C-terminus.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 150 mM NaCl, pH 7.5
- Storage
- -20 °C
- Storage Comment
- -20°C
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- Target
- ITGAV/ITGB5 (Integrin alpha V / beta 5 (ITGAV/ITGB5))
- Alternative Name
- Integrin alpha V beta 5 (ITGAV/ITGB5 Products)
- Background
- Synonyms:Integrin alpha V beta 5,ITGAV&ITGB5,Description:Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.
- Molecular Weight
- 112.3 kDa | 81.7 kDa
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