Oncostatin M Protein (OSM) (AA 27-207) (His tag)

Catalog No. ABIN7504489

Product Details

Target: Oncostatin M (OSM)

Protein Type: Recombinant

Protein Characteristics: AA 27-207

Origin: Dog

Source: HEK-293 Cells

Purification tag / Conjugate: This Oncostatin M protein is labelled with His tag.

Purpose: Canine Oncostatin M/OSM Protein

Sequence: Ser27-Arg207

Characteristics: Recombinant Canine Oncostatin M/OSM Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser27-Arg207.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as 0.22μm filtered solution in PBS ( pH 7.4).

Storage: -80 °C

Storage Comment: Valid for 12 months from date of receipt when stored at -80°C.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Oncostatin M (OSM)

Alternative Name: Oncostatin M (OSM Products)

Synonyms: OSM Protein, OncoM Protein, oncostatin M Protein, OSM Protein, Osm Protein

Background: OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.

Molecular Weight: 21.65 kDa. Due to glycosylation, the protein migrates to 27-35 kDa based on Tris-Bis PAGE result.

UniProt: A0A8I3Q5M1

Pathways: JAK-STAT Signaling, Negative Regulation of Hormone Secretion