PIK3CA Protein (AA 1-200) (His tag)

Catalog No. ABIN7504937

Product Details

Target: PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))

Protein Type: Recombinant

Protein Characteristics: AA 1-200

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This PIK3CA protein is labelled with His tag.

Sequence: Met1-Pro200

Characteristics: A DNA sequence encoding the Human PIK3CA (P42336-1) (Met1-Pro200) was expressed with a polyhistidine tag at the N-terminus.

Purity: >90 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))

Alternative Name: PIK3CA (PIK3CA Products)

Synonyms: CLOVE Protein, CWS5 Protein, MCAP Protein, MCM Protein, MCMTC Protein, PI3K Protein, p110-alpha Protein, C-P3K Protein, PI3-kinase Protein, PI3K-alpha Protein, pi3-k Protein, pi3k Protein, AA414921 Protein, C530050K14 Protein, p50alpha Protein, p55alpha Protein, p85alpha Protein, 6330412C24Rik Protein, caPI3K Protein, p110 Protein, p110alpha Protein, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Protein, Phosphoinositide-3-kinase, catalytic, alpha polypeptide Protein, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Protein, phosphoinositide-3-kinase regulatory subunit 1 Protein, PIK3CA Protein, GL50803_14855 Protein, pik3ca Protein, Pik3ca Protein, Pik3r1 Protein

Background:

Background: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22.

Synonym: 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,5-bisphosphate 3-kinase catalytic subunit alpha isoform, caPI3K,CLOVE,CWS5,MCAP,MCM,MCMTC,MGC142161,MGC142163,p110 alpha,p110alpha,Phosphatidylinositol 3 kinase catalytic alpha polypeptide,Phosphatidylinositol 3 kinase catalytic 110 KD alpha,Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha,Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform,Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha,Phosphatidylinositol-4,Phosphoinositide 3 kinase catalytic alpha polypeptide,PI3 kinase p110 subunit alpha,PI3-kinase subunit alpha,PI3K,PI3K-alpha,PI3KC A,PIK3C A,Pik3ca,PK3CA,PK3CA,PtdIns 3 kinase p110,PtdIns-3-kinase subunit alpha,PtdIns-3-kinase subunit p110-alpha,Serine/threonine protein kinase PIK3CA

Molecular Weight: 23.1 kDa

Pathways: PI3K-Akt Signaling, RTK Signaling, TCR Signaling, AMPK Signaling, Interferon-gamma Pathway, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, VEGF Signaling