ITGB1 Protein (His tag)

Catalog No. ABIN7534299

Product Details

Target: ITGB1 (Integrin beta 1 (ITGB1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This ITGB1 protein is labelled with His tag.

Purpose: Recombinant Human ITGB1/CD29 Protein

Sequence: MNLQPIFWIG LISSVCCVFA QTDENRCLKA NAKSCGECIQ AGPNCGWCTN STFLQEGMPT SARCDDLEAL KKKGCPPDDI ENPRGSKDIK KNKNVTNRSK GTAEKLKPED ITQIQPQQLV LRLRSGEPQT FTLKFKRAED YPIDLYYLMD LSYSMKDDLE NVKSLGTDLM NEMRRITSDF RIGFGSFVEK TVMPYISTTP AKLRNPCTSE QNCTSPFSYK NVLSLTNKGE VFNELVGKQR ISGNLDSPEG GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ CHLENNMYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN LIPKSAVGTL SANSSNVIQL IIDAYNSLSS EVILENGKLS EGVTISYKSY CKNGVNGTGE NGRKCSNISI GDEVQFEISI TSNKCPKKDS DSFKIRPLGF TEEVEVILQY ICECECQSEG IPESPKCHEG NGTFECGACR CNEGRVGRHC ECSTDEVNSE DMDAYCRKEN SSEICSNNGE CVCGQCVCRK RDNTNEIYSG KFCECDNFNC DRSNGLICGG NGVCKCRVCE CNPNYTGSAC DCSLDTSTCE ASNGQICNGR GICECGVCKC TDPKFQGQTC EMCQTCLGVC AEHKECVQCR AFNKGEKKDT CTQECSYFNI TKVESRDKLP QPVQPDPVSH CKEKDVDDCW FYFTYSVNGN NEVMVHVVEN PECPTGPD

Specificity: Met1-Asp728

Purity: > 90 % by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: < 0.1 EU/μg of the protein by LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Target Details

Target: ITGB1 (Integrin beta 1 (ITGB1))

Alternative Name: ITGB1/CD29 (ITGB1 Products)

Synonyms: CD29 Protein, FNRB Protein, GPIIA Protein, MDF2 Protein, MSK12 Protein, VLA-BETA Protein, VLAB Protein, 4633401G24Rik Protein, AA409975 Protein, AA960159 Protein, ENSMUSG00000051907 Protein, Fnrb Protein, Gm9863 Protein, gpIIa Protein, cd29 Protein, fnrb Protein, gpiia Protein, itgb1 Protein, mdf2 Protein, msk12 Protein, vla-beta Protein, vlab Protein, itgb1-a Protein, itgb1-b Protein, integrin subunit beta 1 Protein, integrin beta 1 (fibronectin receptor beta) Protein, integrin subunit beta 1 S homeolog Protein, integrin beta 1 Protein, integrin subunit beta 1 L homeolog Protein, ITGB1 Protein, Itgb1 Protein, itgb1.S Protein, LOC100009173 Protein, itgb1.L Protein

Background:

Description: Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling). Integrin beta-1 can help to regulate cell proliferation, cytoskeletal reorganization, and gene expression. Research studies have integrin beta-1 integrin in various activities including embryonic development, blood vessel, skin, bone, and muscle formation, as well as tumor metastasis and angiogenesis.

Name: CD29,FNRB,GPIIA,MDF2,MSK12,VLA-BETA,VLAB,Integrin beta 1,ITGB1,Integrin β1,Integrin-β1/CD29

Gene ID: 3688

UniProt: P05556

Pathways: Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interactome