Oncostatin M Receptor Protein (OSMR) (His tag)

Catalog No. ABIN7520376

Product Details

Target: Oncostatin M Receptor (OSMR)

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This Oncostatin M Receptor protein is labelled with His tag.

Purpose: Recombinant Mouse OSMR/IL-31RB Protein

Sequence: EVLEEPLPLT PEIHKVSFQL KLQEVNLEWT VPALTHEELN MIFQIEISRL NISNTIWVEN YSTTVKREEA VRWNWTSDIP LECVKHFIRI RALVDDTKSL PQSSWGNWSS WKEVNAKVSV EPDKSLIFPK DKVLEEGSNV TICLMYGQNV YNVSCKLQDE PIHGEQLDSH VSLLKLNNVV FLSDTGTNIN CQATKGPKRI FGTVLFVSKV LEEPKNVSCE TRDFKTLDCS WEPGVDTTLT WRKQRFQNYT LCESFSKRCE VSNYRNSYTW QITEGSQEMY NFTLTAENQL RKRSVNINFN LTHRVHPKAP QDVTLKIIGA TKANMTWKVH SHGNNYTLLC QVKLQYGEVI HEHNVSVHMS ANYLFSDLDP DTKYKAFVRC ASANHFWKWS DWTQKEFSTP ETAPSQALDV WRQVWSENGR RIVTLFWKPL LKSQANGKII SYNIVVENEA KPTESEHYCV WAPALSTNLS LDLQPYKIRI TTNNSMGASP ESLMVLSNDS GHEEVKEKTI KGIKDAFNIS WEPVSGDTMG YVVDWCAHSQ DQRCDLQWKN LGPNTTSTTI TSDDFKPGVR YNFRIFERSV EHKARLVEKQ RGYTQELAPL VNPKVEIPYS TPNSFVLRWP DYDSDFQAGF IKGYLVYVKS KEMQCNQPWE RTLLPDNSVL CKYDINGSET KTLTVENLQP ESLYEFFVTP YTSAGPGPNE TFTKVTTPDA RSHM

Specificity: Glu24-Met737

Purity: > 95 % by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: <0.1EU/μg

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Target Details

Target: Oncostatin M Receptor (OSMR)

Alternative Name: OSMR/IL-31RB (OSMR Products)

Synonyms: OSMRB Protein, PLCA1 Protein, oncostatin M receptor Protein, OSMR Protein, Osmr Protein

Background:

Description: Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the type I cytokine receptor family. IL-31RB/OSMR heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in IL-31RB/OSMR have been associated with familial primary localized cutaneous amyloidosis. Defects in IL-31RB/OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1), also known as familial lichen amyloidosis of familial cutaneous lichen amyloidosis. PLCA1 is hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.

Name: IL-31R subunit beta,IL-31R-beta,IL-31RB,OSMR beta,OSMR,OSMRB,OSMR

Gene ID: 18414

UniProt: O70458

Pathways: JAK-STAT Signaling, Growth Factor Binding