SNCA Protein

Catalog No. ABIN7520530

Product Details

Target: SNCA (Synuclein, alpha (SNCA))

Protein Type: Recombinant

Origin: Mouse

Source: Escherichia coli (E. coli)

Purpose: Recombinant Mouse SNCA/Alpha-Synuclein Protein

Sequence: MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA

Specificity: Met1-Ala140

Purity: > 95 % by SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1 EU/μg of the protein by LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Target Details

Target: SNCA (Synuclein, alpha (SNCA))

Alternative Name: SNCA/Alpha-Synuclein (SNCA Products)

Synonyms: snca Protein, MGC64356 Protein, LOC619283 Protein, NACP Protein, alphaSYN Protein, PARK1 Protein, PARK4 Protein, PD1 Protein, synuclein alpha L homeolog Protein, alpha-synuclein Protein, synuclein alpha Protein, synuclein, alpha Protein, snca.L Protein, LOC619283 Protein, SNCA Protein, Snca Protein

Background:

Description: Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but alsoexpressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D andhistones. SNCA can include beta- and gamma-synuclein. In addition, SNCA is an important regulatorycomponent of vesicular transport in neuronal cells. It has been suggested that SNCA is related to thepathogenesis of Parkinson's Disease and neurodegenerative disorders. Defects in SNCA will lead to DementiaLewy Body (DLB).

Name: Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloidprecursor, NACP, Snca

Gene ID: 20617

UniProt: O55042

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity