HRAS Protein (AA 1-186)

Catalog No. ABIN7939165

Recombinant HRAS protein expressed in Escherichia coli (E. coli).

Quick Overview for HRAS Protein (AA 1-186) (ABIN7939165)

Target: HRAS (HRas proto-oncogene, GTPase (HRAS))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Product Details

Protein Characteristics: AA 1-186

Purpose: Recombinant HRAS (1-186) protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant HRAS (1-186) protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: HRAS (HRas proto-oncogene, GTPase (HRAS))

Alternative Name: HRAS

Background:

Protein Background: HRAS (GTPase HRas) protein encoded by HRAS is a GTPase. HRas is a small G protein that belongs to the small GTPase superfamily. When HRas is combined with guanosine triphosphate, it will bind to Raf kinases such as c-Raf and further activate MAPK/ERK path. Mutations in this gene have been associated with a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma.

Short Description: Recombinant HRAS (1-186) protein that includes amino acids 1-186 of human HRAS protein (accession number NP_005334.1) was expressed in E. coli cells with an C-terminal 6xHis tag. The molecular weight of the protein is 22.06 kDa.

Aliases: GTPase HRas, HRAS1, HRas proto-oncogene, GTPase, H-Ras

Pathways: p53 Signaling, MAPK Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Autophagy, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling, BCR Signaling