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Human Monoclonal CD46 Primary Antibody for FACS, IP - ABIN94153
Oliaro, Pasam, Waterhouse, Browne, Ludford-Menting, Trapani, Russell: Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 14 Pubmed References
Human Monoclonal CD46 Primary Antibody for FACS, IP - ABIN94151
Liszewski, Kemper, Price, Atkinson: Emerging roles and new functions of CD46. in Springer seminars in immunopathology 2005
Show all 14 Pubmed References
Human Monoclonal CD46 Primary Antibody for FACS, IP - ABIN94149
Gaggar, Shayakhmetov, Lieber: CD46 is a cellular receptor for group B adenoviruses. in Nature medicine 2003
Show all 13 Pubmed References
Human Monoclonal CD46 Primary Antibody for FACS, IP - ABIN125715
Okada, Liszewski, Atkinson, Caparon: Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. in Proceedings of the National Academy of Sciences of the United States of America 1995
Show all 12 Pubmed References
Human Monoclonal CD46 Primary Antibody for FACS, IP - ABIN94152
Marie, Astier, Rivailler, Rabourdin-Combe, Wild, Horvat: Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation. in Nature immunology 2002
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Human Monoclonal CD46 Primary Antibody for FACS, IP - ABIN192263
Kälin, Amstutz, Gastaldelli, Wolfrum, Boucke, Havenga, DiGennaro, Liska, Hemmi, Greber: Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35. in Journal of virology 2010
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Human Monoclonal CD46 Primary Antibody for FACS, WB - ABIN2191980
Matsui, Sakurai, Katayama, Kurachi, Tashiro, Sugio, Kawabata, Mizuguchi: Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob. in Virus research 2010
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Human Monoclonal CD46 Primary Antibody for FACS, WB - ABIN2191979
Seya, Hara, Matsumoto, Akedo: Quantitative analysis of membrane cofactor protein (MCP) of complement. High expression of MCP on human leukemia cell lines, which is down-regulated during cell differentiation. in Journal of immunology (Baltimore, Md. : 1950) 1990
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Rat (Rattus) Monoclonal CD46 Primary Antibody for IA, IF - ABIN2192126
Mizuno, Harris, Johnson, Morgan: Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3. in Biology of reproduction 2004
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Human adenovirus type 17 from species D transduces endothelial cells and human CD46 is involved in cell entry.
CD46 induced autophagy and decreased the oxidative stress-mediated apoptosis of respiratory epithelium, and this may offer a new therapeutic strategy to treat asthma.
The mAb library and a high-throughput inhibition assay were utilized to identify CD46 as a new factor for human cytomegalovirus (CMV) entry. Study demonstrated that CD46 impacts viral dissemination in epithelial cells and that CD46-dependent entry can occur in trophoblasts, a cell type critical for congenital CMV infection.
Patients receiving a kidney with at least one G allele for the CD46 promoter polymorphism rs2796267 (A/G) showed a lower rejection-free survival, though this became borderline significant after adjustment for potential confounders.
This demonstrates that CD46 is a co-stimulatory receptor on CD8(+) T cells, and that it exerts separate functions during CD4(+) and CD8(+) T-cell differentiation
CD46 delivers co-stimulatory signals for optimal CD8(+) T cell activity by augmenting nutrient-influx and fatty acid synthesis.
Only type-I interferon restricts viral replication of attenuated Measles virus (MV) Schwarz strain in mice, independently of the presence of hCD46 receptor.
CD46 levels were positive in 3.3% (n = 3) and negative in 96.7% (n = 90). Conclusion This study does not support the theory of measles virus as the cause of otosclerosis.
Findings demonstrate that CD46 is a key inhibitor of complement activation whose downregulation may be involved in the pathogenesis of bullous pemphigoid.
these data suggest a possible mechanism underlying the regulatory function of CD46 on T cells.
study demonstratede that MMP-9-mediated shedding of CD46 is an integral part of autocrine Th1 regulation and that this pathway is dysregulated in T cells from patients with systemic lupus erythematosus
the cell surface expression level of CD46 was markedly higher in patient myeloma cells with 1q gain than in those with normal 1q copy number.
Our findings reveal a novel role of CD46 in accelerating inflammatory responses upon meningococcal infection or LPS stimulation by regulating the functional polarization and survival of macrophages.
study reveals common CD46 and IFI44L SNPs associated with measles-specific humoral immunity, and highlights the importance of alternative splicing/virus cellular receptor isoform usage as a mechanism explaining inter-individual variation in immune response after live measles vaccine
study showed no genotype differences in CD46 IVS1-1724 C>G Single nucleotide polymorphis (SNP) between Recurrent Spontaneous Abortion and fertile women
Isoforms of CD46 impact on HHV-6B infection and thereby in part explain the distinct tropism of HHV-6AGS and HHV-6BPL1.
This study suggests that the promoter polymorphism (rs2796267, -496 A/G) CD46 gene may be related to susceptibility of acute renal allograft rejection in Korean kidney transplantation recipients.
provides insight into CD46 alternative splicing regulation with implications for its function in the immune system and for genetic disease
CD46 controls both Th1 activation and regulation via a miR-150-dependent mechanism.
Data show that CD28 antigen costimulation modulates CD46 antigen surface expression on activated T cells.
Changes in CD46 expression may lead to changes in VEGF and play a pathologic role in the development of age-related macular degeneration.
Our findings provide evidence for expression of CD46 in the mouse eye and a role for CD46 in protection against laser-induced choroidal neovascularization
This fusion is mediated by the interaction between viral glycoproteins expressed on the membrane of the infected cells and CD46 on the glial targets, and is also observed using cells expressing recombinant MV glycoproteins.
CD46 isoforms function as receptors for human herpesvirus 6 and measles virus
Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm and increased male fertility
CD46 has a role as a receptor for fusion and entry of human herpesvirus 6 into target cells
The results obtained in this study showed that both porcine CD46 and heparan sulfates play a major role in the initial steps of classical swine fever virus infection.
study found that sCD46 is not detectable in fetal and neonatal sera and that its plasma concentration increases progressively up to adulthood; also detected high- and low-sCD46 performers and show that this phenotype does not depend of environmen.
Study shows the existence of 10 distinct allelic versions of the CCP1 module of CD46; ectopic expression of the 10 bovine CD46 isoforms rendered the PK15 cells permissive to bovine viral diarrhea virus.
localization of CD46 on bovine sperm membrane
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
CD46 antigen, complement regulatory protein
, antigen identified by monoclonal antibody TRA-2-10
, complement membrane cofactor protein
, measles virus receptor
, membrane cofactor protein
, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
, trophoblast leucocyte common antigen
, trophoblast leukocyte common antigen
, trophoblast-lymphocyte cross-reactive antigen
, brain microvascular membrane cofactor
, membrane cofactor protein(GMP1-full)