Browse our anti-CD46 Molecule, Complement Regulatory Protein (CD46) Antibodies

Human CD46 Molecule, Complement Regulatory Protein (CD46) interaction partners

1. The mAb library and a high-throughput inhibition assay were utilized to identify CD46 as a new factor for human cytomegalovirus (CMV) entry. Study demonstrated that CD46 impacts viral dissemination in epithelial cells and that CD46-dependent entry can occur in trophoblasts, a cell type critical for congenital CMV infection.

2. Patients receiving a kidney with at least one G allele for the CD46 promoter polymorphism rs2796267 (A/G) showed a lower rejection-free survival, though this became borderline significant after adjustment for potential confounders.

3. This demonstrates that CD46 is a co-stimulatory receptor on CD8(+) T cells, and that it exerts separate functions during CD4(+) and CD8(+) T-cell differentiation

4. CD46 delivers co-stimulatory signals for optimal CD8(+) T cell activity by augmenting nutrient-influx and fatty acid synthesis.

5. Only type-I interferon restricts viral replication of attenuated Measles virus (MV) Schwarz strain in mice, independently of the presence of hCD46 receptor.

6. CD46 levels were positive in 3.3% (n = 3) and negative in 96.7% (n = 90). Conclusion This study does not support the theory of measles virus as the cause of otosclerosis.

7. Findings demonstrate that CD46 is a key inhibitor of complement activation whose downregulation may be involved in the pathogenesis of bullous pemphigoid.

8. these data suggest a possible mechanism underlying the regulatory function of CD46 on T cells.

9. study demonstratede that MMP-9-mediated shedding of CD46 is an integral part of autocrine Th1 regulation and that this pathway is dysregulated in T cells from patients with systemic lupus erythematosus

10. the cell surface expression level of CD46 was markedly higher in patient myeloma cells with 1q gain than in those with normal 1q copy number.

11. Our findings reveal a novel role of CD46 in accelerating inflammatory responses upon meningococcal infection or LPS stimulation by regulating the functional polarization and survival of macrophages.

12. study reveals common CD46 and IFI44L SNPs associated with measles-specific humoral immunity, and highlights the importance of alternative splicing/virus cellular receptor isoform usage as a mechanism explaining inter-individual variation in immune response after live measles vaccine

13. study showed no genotype differences in CD46 IVS1-1724 C>G Single nucleotide polymorphis (SNP) between Recurrent Spontaneous Abortion and fertile women

14. Isoforms of CD46 impact on HHV-6B infection and thereby in part explain the distinct tropism of HHV-6AGS and HHV-6BPL1.

15. This study suggests that the promoter polymorphism (rs2796267, -496 A/G) CD46 gene may be related to susceptibility of acute renal allograft rejection in Korean kidney transplantation recipients.

16. provides insight into CD46 alternative splicing regulation with implications for its function in the immune system and for genetic disease

17. CD46 controls both Th1 activation and regulation via a miR-150-dependent mechanism.

18. Data show that CD28 antigen costimulation modulates CD46 antigen surface expression on activated T cells.

19. This review summarizes our current knowledge of disease-associated mutations in this complement inhibitor(CD46).

20. It was not discover any association between A304V or other CD46 SNPs and preeclampsia.

Mouse (Murine) CD46 Molecule, Complement Regulatory Protein (CD46) interaction partners

1. Changes in CD46 expression may lead to changes in VEGF and play a pathologic role in the development of age-related macular degeneration.

2. Our findings provide evidence for expression of CD46 in the mouse eye and a role for CD46 in protection against laser-induced choroidal neovascularization

3. This fusion is mediated by the interaction between viral glycoproteins expressed on the membrane of the infected cells and CD46 on the glial targets, and is also observed using cells expressing recombinant MV glycoproteins.

4. CD46 isoforms function as receptors for human herpesvirus 6 and measles virus

5. Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm and increased male fertility

6. CD46 has a role as a receptor for fusion and entry of human herpesvirus 6 into target cells

Pig (Porcine) CD46 Molecule, Complement Regulatory Protein (CD46) interaction partners

1. The results obtained in this study showed that both porcine CD46 and heparan sulfates play a major role in the initial steps of classical swine fever virus infection.

Cow (Bovine) CD46 Molecule, Complement Regulatory Protein (CD46) interaction partners

1. study found that sCD46 is not detectable in fetal and neonatal sera and that its plasma concentration increases progressively up to adulthood; also detected high- and low-sCD46 performers and show that this phenotype does not depend of environmen.

2. Study shows the existence of 10 distinct allelic versions of the CCP1 module of CD46; ectopic expression of the 10 bovine CD46 isoforms rendered the PK15 cells permissive to bovine viral diarrhea virus.

3. localization of CD46 on bovine sperm membrane