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Human SMURF1 Protein expressed in Wheat germ - ABIN1320726
Wang, Zhang, Weng, Qiao, Ma, Xiao, Yu, Pan, Sun et al.: Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in ... in The Journal of biological chemistry 2013
Nedd8 (show NEDD8 Proteins) binding to Smurf plays important roles in the regulation of cell migration and the BMP and TGFbeta (show TGFB1 Proteins) signaling pathways.
Expression of Smurf1 was increased with WHO grade and was consistent with poor prognosis of gliomas.
Smurf1 interacts with and targets Securin (show PTTG1 Proteins), an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation.
Smurf1 overexpression decreases USP25 (show USP25 Proteins) protein turnover, and the E3 ligase enzymatic activity of Smurf1 is required for USP25 (show USP25 Proteins) degradation.
SMURF1 can be potentially used as a clinical biomarker and target for novel treatment of human GC.
Uev1A (show UBE2V1 Proteins) appears to be involved in the BMP signaling pathway in which it collaborates with a ubiquitin E3 ligase Smurf1 to promote Smad1 (show GARS Proteins) degradation in a Ubc13 (show UBE2N Proteins)-independent manner.
High smurf1 expression is associated with neoplasms.
activation of AMPK (show PRKAA1 Proteins) upregulated Smad6 (show SMAD6 Proteins) and Smurf1 and thereby enhanced their interactions, resulting in its proteosome-dependent degradation of ALK2 (show ACRV1 Proteins).
we propose that the PKA-Smurf1-PIPKIgamma pathway has an important role in pulmonary tumorigenesis and imposes substantial clinical impact on development of novel diagnostic markers and therapeutic targets for lung cancer treatment.
SMU (show MLXIP Proteins)RF1 is increased in patients with pulmonary arterial hypertension
Six2 (show SIX2 Proteins) mediates the protective effects of GDNF on damaged DA neurons by regulating Smurf1 expression.
TGF-beta (show TGFB1 Proteins) inhibited osteoblastic differentiation by inducing the MAPK-ERK (show MAPK1 Proteins) pathway which upregulated the expression of ubiquitin ligase (show RNF123 Proteins) SMURF1 and resulted in reduced presence of osteogenic proteins.
demonstration that Smurf1 acts as a brake for integrin activation by controlling Kindlin-2 (show FERMT2 Proteins) protein levels, a new mechanism that permits precise modulation of integrin-mediated cellular functions
miR (show MLXIP Proteins)-140-5p and SMURF1 are key regulators of disease pathology in pulmonary arterial hypertension
Smurf1 is required for selective autophagy of Mycobacterium tuberculosis and host defense against tuberculosis infection.
Smurf1 regulates glucose metabolism and inhibits osteoblast differentiation. Smurf1 function requires the presence of serine 148 (S148) in Smurf1.
Smurf1 mediates NGF (show NGFB Proteins) signaling and ubiquitinates RhoA (show RHOA Proteins) in growth cones, regulating the need for local translation and degradation.
Smurf-mediated endocytosis of Patched1 (show PTCH1 Proteins) is required in sonic hedgehog (show SHH Proteins) signal reception
Inhibition of rhBMP-2-induced ALP (show CCL21A Proteins) activity by intracellular delivery of SMURF1 in murine calvarial preosteoblast cells.
Data demonstrate that Smurf1 and Smurf2 (show SMURF2 Proteins) have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.
In Xenopus embryos, the BMP pathway is a major physiological target of Smurf1. We propose that in normal development Smurf1 cooperates with secreted BMP antagonists to limit BMP signaling in dorsal ectoderm.
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.
Smad ubiquitination regulatory factor 1
, E3 ubiquitin-protein ligase SMURF1
, SMAD specific E3 ubiquitin protein ligase 1
, e3 ubiquitin-protein ligase SMURF1-like
, E3 ubiquitin ligase SMURF1
, SMAD-specific E3 ubiquitin-protein ligase 1
, Smad-specific E3 ubiquitin ligase 1
, SMAD ubiquitination regulatory factor 1