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|Antigen||Methionyl Aminopeptidase 2 (METAP2) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
Western Blotting (WB)
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|Specificity||METAP2 antibody was raised against the N terminal of METAP2|
|Immunogen||METAP2 antibody was raised using the N terminal of METAP2 corresponding to a region with amino acids ATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGR|
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|Alternative Name||METAP2 (METAP2 Antibody Abstract)|
|Background||METAP2 is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site.|
|Molecular Weight||53 kDa (MW of target protein)|
|Pathways||Regulation of G-Protein Coupled Receptor Protein Signaling|
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WB: 0.5 µg/mL
Optimal conditions should be determined by the investigator.
METAP2 Blocking Peptide, catalog no. 33R-1556, is also available for use as a blocking control in assays to test for specificity of this METAP2 antibody
|Restrictions||For Research Use only|
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|Reconstitution||Lyophilized powder. Add distilled water for a 1 mg/mL concentration of METAP2 antibody in PBS|
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.
|Storage Comment||Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.|
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