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|Antigen||Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) Antibodies|
|Epitope||AA 2150-2210 Alternatives|
|Reactivity||Rat (Rattus), Mouse (Murine) Alternatives|
|Conjugate||This CACNA1A antibody is un-conjugated Alternatives|
Immunohistochemistry (IHC), Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-CACNA1A AntibodyTarget Details CACNA1A Application Details Handling Images
|Specificity||Specific for CACNA1A.|
|Immunogen||A synthetic peptide from aa region of 2150-2210 of rat CACNA1A conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse.|
|Plasmids, Primers & others|
Target Details CACNA1AProduct Details anti-CACNA1A Antibody Application Details Handling Images back to top
|Alternative Name||CACNA1A (CACNA1A Antibody Abstract)|
FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA). SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein. Tissue specificity: Brain specific, mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells.
Synonyms: BI, Brain calcium channel I, Cach4, Cacn3, Cacna1a, Cacnl1a4, Calcium channel L type alpha-1 polypeptide, Voltage-dependent P/Q-type calcium channel alpha-1A subunit, Voltage-gated calcium channel alpha subunit Cav2.1
|Pathways||Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process|
Application DetailsProduct Details anti-CACNA1A Antibody Target Details CACNA1A Handling Images back to top
A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user. Not tested in other applications.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CACNA1A Antibody Target Details CACNA1A Application Details Images back to top
|Reconstitution||Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.|
|Handling Advice||Avoid freeze and thaw cycles.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Expiry Date||12 months|