anti-Human serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 Antibody (supplied by: Log in to see )

Antigen
serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) Antibodies
  • CG9453
  • Dmel\\CG9453
  • Serp2
  • Sp4
  • Spn4
  • Spn4A
  • dSerp2
  • sp4
  • spn4
  • SERPINI1
  • pi12
  • neuroserpin
  • AI837402
  • Ns
  • PI-12
  • PI12
  • Spi17
  • raPIT5a
  • Serpin 42Da
  • serpin family I member 1
  • serine (or cysteine) peptidase inhibitor, clade I, member 1
  • Spn42Da
  • SERPINI1
  • serpini1
  • Serpini1
Epitope
AA 26-53, N-Term
18
15
11
9
8
8
4
4
3
2
1
1
1
1
Reactivity
Human
115
55
35
3
3
3
3
3
2
2
2
1
1
1
1
1
Host
Rabbit
82
19
16
13
2
Clonality
Polyclonal
Conjugate
Un-conjugated
12
8
8
5
5
5
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
106
75
30
18
18
18
13
7
6
2
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Available images

Catalog No. ABIN953686
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
12.85828 ABIN4352977 IHC IHC (p) Rabbit IgG Log in to see Polyclonal 0
12.85828 ABIN4352976 IHC IHC (p) Rabbit Log in to see Polyclonal 0
1 ABIN654346 FACS IF IHC (p) WB Rabbit Ig Fraction AA 19-45, N-Term Log in to see Polyclonal 0
1 ABIN790558 IHC (p) ELISA WB Mouse IgG1, kappa AA 17-411 Log in to see 1D10 0
1 ABIN562219 IHC (p) ELISA WB Mouse IgG1 kappa AA 17-410, full length Log in to see 1D10 1
1 ABIN1998281 IHC (p) ELISA WB Rabbit IgG AA 1-410 Log in to see Polyclonal 0
1 ABIN5535639 FACS IF IHC (p) WB Rabbit Ig Fraction AA 19-45, N-Term Log in to see Polyclonal 0
1 ABIN782430 EIA IHC (p) WB Mouse IgG1 AA 17-411 Log in to see 1D10 0
1 ABIN1408448 IHC (p) WB HRP Rabbit IgG Log in to see Polyclonal 0
1 ABIN1390555 IHC (p) WB Biotin Rabbit IgG Log in to see Polyclonal 0
1 ABIN1386509 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN1723901 IHC (p) ELISA WB Mouse IgG1 kappa AA 17-411, full length Log in to see 1D10 0
1 ABIN1814470 FACS IF IHC (p) WB Rabbit AA 19-45 Log in to see Polyclonal 0
1 ABIN2586039 ELISA IHC (p) WB Mouse IgG1 AA 17-411 Log in to see 0
1 ABIN5587767 IHC (p) Rabbit IgG Log in to see Polyclonal 0
1 ABIN5508397 ELISA IHC (p) Mouse IgG1 AA 1-410 Log in to see 08 0
1 ABIN2770620 IHC (p) IHC ELISA WB Mouse IgG1, kappa Log in to see 1D10 0

General

Antigen serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) Antibodies
Epitope AA 26-53, N-Term
(18), (15), (11), (9), (8), (8), (4), (4), (3), (2), (1), (1), (1), (1)
Reactivity Human
(115), (55), (35), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Host Rabbit
(82), (19), (16), (13), (2)
Clonality
Polyclonal
Conjugate Un-conjugated
(12), (8), (8), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(106), (75), (30), (18), (18), (18), (13), (7), (6), (2), (1), (1)
Pubmed 5 references available
Supplier Log in to see

Product details

Target Details Application Details Handling References Images
Specificity Recognizes SERPINI1 (N-term).
Purification Protein A column followed by peptide Affinity purification
Immunogen KLH conjugated synthetic peptide between 26-53 amino acids from the N-terminal region of Human SERPINI1. Genename: SERPINI1
Isotype Ig Fraction

Target Details

Product details Application Details Handling References Images back to top
Antigen
Alternative Name Neuroserpin / SERPINI1 (SERPINI1 Antibody Abstract)
Background This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.Synonyms: PI-12, PI12, Peptidase inhibitor 12, Serpin I1
Gene ID 5274
NCBI Accession NP_001116224
Pathways Regulation of Hormone Metabolic Process

Application Details

Product details Target Details Handling References Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product details Target Details Application Details References Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References

Product details Target Details Application Details Handling Images back to top
Background publications

Takehara, Zhang, Yang, Takahashi, Mikami, Onda: "Refolding and polymerization pathways of neuroserpin." in: Journal of molecular biology, Vol. 403, Issue 5, pp. 751-62, 2010

Han, Lan, Park, Lee, Park, Ahn, Shin, Kang, Koo, Seo, Choi, Ahn, Chanock, Kim, Rothman, Kang: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010

Rajaraman, Brenner, Neta, Pfeiffer, Wang, Yeager, Thomas, Fine, Linet, Rothman, Chanock, Inskip: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010

Davies, Miranda, Roussel, Kaufman, Marciniak, Lomas: "Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response." in: The Journal of biological chemistry, Vol. 284, Issue 27, pp. 18202-9, 2009

Rajaraman, Brenner, Butler, Wang, Pfeiffer, Ruder, Linet, Yeager, Wang, Orr, Fine, Kwon, Thomas, Rothman, Inskip, Chanock: "Common variation in genes related to innate immunity and risk of adult glioma." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1651-8, 2009

Images

Product details Target Details Application Details Handling References back to top
Supplier Images
Immunofluorescence (IF) image for anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 26-53), (N-Term) antibody (ABIN953686) Confocal Immunofluorescent analysis of SERPINI1 Antibody (N-term)Cat.-No AP53865PU-N ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 26-53), (N-Term) antibody (ABIN953686) Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human brain tissue...
Western Blotting (WB) image for anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 26-53), (N-Term) antibody (ABIN953686) Western blot analysis using SERPINI1 Antibody (N-term) Cat.-No AP53865PU-N in HepG2 c...