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expression of mPL-II and Igf2 is highly related to placental development in mice
results are consistent with a pleiotropic effect of placental hGH/CSH (show CSH1 Proteins) genes at the maternal-fetal interface relating to the regulation of fetal growth and the risk of affected maternal metabolism.
Data conclude that members of the C/EBP (show CEBPA Proteins) and Ets (show ETS1 Proteins) families can differentially modulate CS-Benh and CS-Aenh activity.
Cpn10 (show HSPE1 Proteins) and placental lactogen (show CSH1 Proteins) are capable of stimulating the synthesis of type I collagen by human osteoblasts in culture
Dysregulation of PL and leptin (show LEP Proteins) in nuclear transfer placentomes could affect cell migration and invasion and subsequently placental metabolism and transfer of nutrients to fetus, leading to increased placental and fetal macrosomia.
Serum free culture conditions significantly enhanced Cyp17 (show CYP17A1 Proteins) and Csh1 (show PRL3D1 Proteins) but not Hsd3b (show HSD3B1 Proteins) expression in trophoblast.
This is the first report to identify the differential regulatory mechanisms of the bCSH1 and bPRP1 genes and indicates that bCSH1 might potentially be the only transcript that is subject to DNA methyltransferase (show DNMT1 Proteins) regulation.
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation\; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity.
, chorionic somatomammotropin hormone 2
, placental lactogen 2
, placental lactogen II
, chorionic somatomammotropin-2
, chorionic somatomammotropin-3
, chorionic somatomammotropin B
, placental lactogen
, chorionic somatomammotropin hormone 1 (placental lactogen)
, placental lactogen I