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|Antigen||Fibroblast Growth Factor 2 (Basic) (FGF2) Antibodies|
|Epitope||AA 1-155 Alternatives|
|Reactivity||Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This FGF2 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-FGF2 AntibodyTarget Details FGF2 Application Details Handling References for anti-FGF2 antibody (ABIN967726) Images
|Cross-Reactivity||Mouse (Murine), Rat (Rattus), Dog (Canine), Chicken|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human bFGF aa. 1-155|
Target Details FGF2Product Details anti-FGF2 Antibody Application Details Handling References for anti-FGF2 antibody (ABIN967726) Images back to top
|Alternative Name||basic FGF (FGF2 Antibody Abstract)|
|Background||Basic Fibroblast Growth Factor (bFGF) is a family member of the cell-differentiating and growth promoting factors. Basic FGF exists as multiple isoforms ranging from 18-24kDa that are derived from a single mRNA species under unique translational conditions. The 18kDa isoform is primarily cytosolic, but is also secreted and may form reservoirs of bFGF in the extracellular matrix. In contrast, the larger isoforms are predominantly nuclear. At the cellular level, bFGF is a potent mitogen and promotes cell survival by inhibiting apoptosis. At the tissue level, it is involved in wound repair and induces angiogenesis. In addition, bFGF is a significant target in cancer research because it is over-expressed in some cancers and may enhance a tumor's metastatic potential.|
|Molecular Weight||18-24 kDa|
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, C21-Steroid Hormone Metabolic Process, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Protein targeting to Nucleus|
Application DetailsProduct Details anti-FGF2 Antibody Target Details FGF2 Handling References for anti-FGF2 antibody (ABIN967726) Images back to top
Related Products: ABIN968545, ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-FGF2 Antibody Target Details FGF2 Application Details References for anti-FGF2 antibody (ABIN967726) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20°C.|
References for anti-FGF2 antibody (ABIN967726)Product Details anti-FGF2 Antibody Target Details FGF2 Application Details Handling Images back to top
|Product cited in:||
Yaccoby, Johnson, Mahaffey, Wezeman, Barlogie, Epstein: "Antimyeloma efficacy of thalidomide in the SCID-hu model." in: Blood, Vol. 100, Issue 12, pp. 4162-8, 2002
Peng, Moffett, Myers, Fang, Stachowiak, Maher, Kratz, Hines, Fluharty, Mizukoshi, Bloom, Stachowiak: "Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors." in: Molecular biology of the cell, Vol. 12, Issue 2, pp. 449-62, 2001
Estival, Monzat, Miquel, Gaubert, Hollande, Korc, Vaysse, Clemente: "Differential regulation of fibroblast growth factor (FGF) receptor-1 mRNA and protein by two molecular forms of basic FGF. Modulation of FGFR-1 mRNA stability." in: The Journal of biological chemistry, Vol. 271, Issue 10, pp. 5663-70, 1996
Fox, Shanley: "Antisense inhibition of basic fibroblast growth factor induces apoptosis in vascular smooth muscle cells." in: The Journal of biological chemistry, Vol. 271, Issue 21, pp. 12578-84, 1996
Stachowiak, Moffett, Joy, Puchacz, Florkiewicz, Stachowiak: "Regulation of bFGF gene expression and subcellular distribution of bFGF protein in adrenal medullary cells." in: The Journal of cell biology, Vol. 127, Issue 1, pp. 203-23, 1994
ImagesProduct Details anti-FGF2 Antibody Target Details FGF2 Application Details Handling References for anti-FGF2 antibody (ABIN967726) back to top