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|Antigen||Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) Antibodies|
|Epitope||AA 1160-1210 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This FLT1 antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|3 references available|
|Supplier||Log in to see|
Product Details anti-FLT1 AntibodyTarget Details FLT1 Application Details Handling References for anti-FLT1 antibody (ABIN725795) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from rat VEGFR1|
Target Details FLT1Product Details anti-FLT1 Antibody Application Details Handling References for anti-FLT1 antibody (ABIN725795) Images back to top
|Alternative Name||VEGFR1 (FLT1 Antibody Abstract)|
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, and proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts. Has very high affinity for VEGFA and relatively low protein kinase activity, may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to the activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC, YES1 and PLCG, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 and PTK2/FAK1 (By similarity).
Subcellular location: Cytoplasm
Synonyms: VEGFR-1, Vascular endothelial growth factor receptor 1, Fms-like tyrosine kinase 1, FLT-1, Tyrosine-protein kinase receptor FLT, Flt1, Vegfr1
|Pathways||RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals|
Application DetailsProduct Details anti-FLT1 Antibody Target Details FLT1 Handling References for anti-FLT1 antibody (ABIN725795) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-FLT1 Antibody Target Details FLT1 Application Details References for anti-FLT1 antibody (ABIN725795) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-FLT1 antibody (ABIN725795)Product Details anti-FLT1 Antibody Target Details FLT1 Application Details Handling Images back to top
|Product cited in:||
Liu, Zou, Li, Wang, Wang, Hao, Ke, Li: "RUNX3 modulates hypoxia-induced endothelial-to-mesenchymal transition of human cardiac microvascular endothelial cells." in: International journal of molecular medicine, Vol. 40, Issue 1, pp. 65-74, 2017 Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Human).
Cheng, Xiang, Yang, Ma, Zhao: "Direct Effects of Bevacizumab on Rat Conjunctival Fibroblast." in: Cell biochemistry and biophysics, 2015 (Sample species: Rat (Rattus)).
Liu, Wang, Wang, Wang, Xue: "Paeoniflorin attenuates A?1-42-induced inflammation and chemotaxis of microglia in vitro and inhibits NF-?B- and VEGF/Flt-1 signaling pathways." in: Brain research, Vol. 1618, pp. 149-58, 2015 Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)). Further details: Sample: Brain
ImagesProduct Details anti-FLT1 Antibody Target Details FLT1 Application Details Handling References for anti-FLT1 antibody (ABIN725795) back to top