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Rare inherited and de novo variants in 2,871 congenital heart disease probands identified GDF1 (show GDF1 Proteins), MYH6 (show MYH6 Proteins), and FLT4 as causative genes.
Data show that VEGF-C (show VEGFC Proteins), VEGF-D (show Figf Proteins), and VEGFR-3 were expressed in a substantial percentage of breast carcinomas.
There was a significant decrease in VEGFR3 expression in pulmonary arterial endothelial cells from pulmonary arterial hypertension patients.
By treating LECs with VEGF (show VEGFA Proteins)-C156S and analyzing subsequent changes in gene expression, we identified several 'immediate early (show JUN Proteins)' transcription factors that showed a rapid transient upregulation VEGFR-3 stimulation. these results reveal an important and unanticipated role of HOXD10 (show HOXD10 Proteins) in the regulation of VEGFR-3 signaling in lymphatic endothelial cells, and in the control of lymphangiogenesis and permeability.
The normalized methylation values for the VEGFR1 (show FLT1 Proteins), VEGFR2 (show KDR Proteins) and VEGFR3 promoters tended to be higher in the tumour cell lines than in normal tonsil samples, whereas amounts of VEGFR1 (show FLT1 Proteins), VEGFR2 (show KDR Proteins) and VEGFR3 messenger RNA were significantly higher
These results indicate that VEGF-C (show VEGFC Proteins)-induced MSC (show MSC Proteins) osteogenesis is mediated through VEGFR2 (show KDR Proteins) and VEGFR3, and followed the activation of the ERK (show EPHB2 Proteins)/RUNX2 (show RUNX2 Proteins) signaling pathway.
Assessment of VEGFR-2/VEGFR (show KDR Proteins)-3 on tumor samples might serve as a putative prognostic factor in renal cell carcinoma (show MOK Proteins) cases, identifying a subset of patients that may benefit from antiangiogenic treatments targeting VEGFR (show KDR Proteins) receptors.
This study suggests that NRP1 (show NELL1 Proteins) expression and LVD are independent factors that are likely to predict the risk of LN metastasis in squamous cell carcinoma (SCC (show CYP11A1 Proteins))of the tongue, whereas the expression of VEGFC (show VEGFC Proteins), VEGFR3, CCR7 (show CCR7 Proteins), and SEMA3E (show SEMA3E Proteins) are nonindependent predictive factors
Data indicate that vascular endothelial growth factor D (VEGF-D (show Figf Proteins)) was the best indicator of metastasis and vascular endothelial growth factors and receptor-3 (VEGFR-3) may help to determine the prognosis and management of colorectal cancer (CRC (show CALR Proteins)).
The summarizes the structure and function features of pathway-related molecules of VEGFC (show VEGFC Proteins)/D-VEGFR3/NRP2 (show NELL2 Proteins) axis, stages of various tumors and their molecular mechanisms and significances in tuthe expression changes of these molecules in different anatomic organs or histopathologic types or development lymphatic metastasis.
Report the generation of a Vegfr3-CreER (T2) knockin mouse by gene targeting in embryonic stem cells. This mouse expresses the tamoxifen-inducible CreER(T2) recombinase (show RAG1 Proteins) under the endogenous transcriptional control of the Vegfr3 gene without altering its physiological expression or regulation in the lymphatic system.
Lymphangiogenic growth in the diaphragm was highly dependent on vascular endothelial growth factor receptor (show RYK Proteins) (VEGFR)-3 signaling. During diaphragm development, macrophages appeared first in a linearly arranged pattern, followed by ingrowth of lymphatic vessels along these patterned lines.
CLEC14A (show CLEC14A Proteins) acts in vascular homeostasis by fine-tuning VEGFR-2 (show KDR Proteins) and VEGFR-3 signaling in endothelial cells
VEGFR3 limits VEGFR2 (show KDR Proteins) expression and VEGF (show VEGFA Proteins)/VEGFR2 (show KDR Proteins) pathway activity in quiescent and angiogenic blood vascular endothelial cells, thereby preventing excessive vascular permeability.
Blockade of FLT4 suppresses metastasis of melanoma cells by impaired lymphatic vessels.
Vegf-d (show Figf Proteins) and its receptor Vegfr-3 were more highly expressed in lungs of hyperoxic, versus normoxic, wild-type mice, indicating that components of the Vegf-d (show Figf Proteins) signalling pathway are up-regulated in hyperoxia.
this study uncovers a unique molecular mechanism of lymphangiogenesis in which galectin-8 (show LGALS8 Proteins)-dependent crosstalk among VEGF-C (show VEGFC Proteins), podoplanin (show PDPN Proteins) and integrin pathways plays a key role.
Tnfsf15 (show TNFSF15 Proteins), a cytokine produced largely by endothelial cells, facilitates lymphangiogenesis by up-regulating Vegfr3 gene expression in LECs, contributing to the maintenance of the homeostasis of the circulatory system.
Results showed that the VEGF-C (show VEGFC Proteins)/VEGFR-3 system underlies the protective effect of ischemic preconditioning against forebrain ischemia in the mouse hippocampus
Experiments in mice and zebrafish demonstrate that changing levels of VEGFR3/Flt4 modulates aortic lumen diameter consistent with flow-dependent remodeling
miR (show MYLIP Proteins)-126a directs lymphatic endothelial cell sprouting and extension by interacting with Cxcl12a-mediated chemokine (show CCL1 Proteins) signaling and Vegfc (show VEGFC Proteins)-Flt4 signal axis.
Ca(2 (show CA2 Proteins)+) oscillations depended upon VEGF receptor-2 (Vegfr2) and Vegfr3 in endothelial cells budding from the dorsal aorta (DA) and posterior cardinal (show CARD8 Proteins) vein, respectively.
In the embryo, phenotypes driven by increased Vegfc (show VEGFC Proteins) are suppressed in the absence of Ccbe1 (show CCBE1 Proteins), and Vegfc (show VEGFC Proteins)-driven sprouting is enhanced by local Ccbe1 (show CCBE1 Proteins) overexpression. Moreover, Vegfc (show VEGFC Proteins)- and Vegfr3-dependent Erk (show MAPK1 Proteins) signaling is impaired in the absence of Ccbe1 (show CCBE1 Proteins).
Flt4 plays an essential role in lymphangiogenesis [review]
The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc (show VEGFC Proteins)/Vegfr3 signaling in zebrafish.
Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
flt4 signalling is suppressed by Dll4 (show DLL4 Proteins) in developing zebrafish intersegmental arteries.
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.
, fms-like tyrosine kinase 4
, soluble VEGFR3 variant 1
, soluble VEGFR3 variant 2
, soluble VEGFR3 variant 3
, tyrosine-protein kinase receptor FLT4
, vascular endothelial growth factor receptor 3
, chylous ascites
, receptor protein tyrosine kinase
, vascular endothelial growth factor receptor-3
, FMS-like tyrosine kinase 4
, tyrosine kinase VEGFR-3
, receptor tyrosine kinase Flt4