|Antigen||Insulin-Like Growth Factor 1 Receptor (IGF1R) Antibodies|
|Conjugate||This IGF1R antibody is un-conjugated Alternatives|
Fluorescence Microscopy (FM), Flow Cytometry (FACS)
|3 references available|
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Product Details anti-IGF1R AntibodyTarget Details IGF1R Application Details Handling References for anti-IGF1R antibody (ABIN967487) Images
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
Target Details IGF1RProduct Details anti-IGF1R Antibody Application Details Handling References for anti-IGF1R antibody (ABIN967487) Images back to top
|Alternative Name||CD221 (IGF1R Antibody Abstract)|
Reacts with human insulin-like growth factor-I (IGF-I) receptor alpha subunit (135 kDa). IGF-IRalpha is a glycoprotein complex composed of two extracellular alpha subunits and two transmembrane beta subunits. The transmembrane subunits play a role in tyrosine phosphorylation of several intracellular signaling proteins. IGF-IRalpha is structurally and functionally similar to insulin receptor and is expressed on a variety of human hematopoietic and non-hematopoietic cells. It mediates the effects of IGF-I and IGF-II on cellular growth. 1H7 does not cross react with human insulin receptor and it can block IGF-I or IGF-II stimulated cell growth. This antibody is routinely tested by flow cytometric analysis.
Synonyms: IGF-I Receptor alpha
|Pathways||RTK Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy|
Application DetailsProduct Details anti-IGF1R Antibody Target Details IGF1R Handling References for anti-IGF1R antibody (ABIN967487) Images back to top
|Application Notes||This product is routinely tested on peripheral blood granulocytes. The histogram is an example of the expected reactivity.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IGF1R Antibody Target Details IGF1R Application Details References for anti-IGF1R antibody (ABIN967487) Images back to top
|Buffer||Aqueous buffered solution containing ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at 4° C.|
References for anti-IGF1R antibody (ABIN967487)Product Details anti-IGF1R Antibody Target Details IGF1R Application Details Handling Images back to top
|Product cited in:||
Kooijman, Scholtens, Rijkers, Zegers: "Differential expression of type I insulin-like growth factor receptors in different stages of human T cells." in: European journal of immunology, Vol. 25, Issue 4, pp. 931-5, 1995
Li, Kato, Paz, Kasuya, Fujita-Yamaguchi: "Two new monoclonal antibodies against the alpha subunit of the human insulin-like growth factor-I receptor." in: Biochemical and biophysical research communications, Vol. 196, Issue 1, pp. 92-8, 1993
Xiong, Kasuya, Li, Kato, Fujita-Yamaguchi: "Growth-stimulatory monoclonal antibodies against human insulin-like growth factor I receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 12, pp. 5356-60, 1992
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