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|Antigen||Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) Antibodies|
|Conjugate||This ROR2 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-ROR2 AntibodyTarget Details ROR2 Application Details Handling References for anti-ROR2 antibody (ABIN359932) Images
|Specificity||This antibody reacts to ROR2.|
|Purification||Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a recombinant protein of human ROR2.|
Target Details ROR2Product Details anti-ROR2 Antibody Application Details Handling References for anti-ROR2 antibody (ABIN359932) Images back to top
|Alternative Name||ROR2 (ROR2 Antibody Abstract)|
|Background||ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.Synonyms: NTRKR2, Tyrosine-protein kinase transmembrane receptor ROR2|
|Gene ID||4920, 9606|
|Pathways||RTK Signaling, WNT Signaling|
Application DetailsProduct Details anti-ROR2 Antibody Target Details ROR2 Handling References for anti-ROR2 antibody (ABIN359932) Images back to top
ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-ROR2 Antibody Target Details ROR2 Application Details References for anti-ROR2 antibody (ABIN359932) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-ROR2 antibody (ABIN359932)Product Details anti-ROR2 Antibody Target Details ROR2 Application Details Handling Images back to top
Afzal, Rajab, Fenske, Oldridge, Elanko, Ternes-Pereira, Tüysüz, Murday, Patton, Wilkie, Jeffery: "Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2." in: Nature genetics, Vol. 25, Issue 4, pp. 419-22, 2000
Oldridge, Fortuna, Maringa, Propping, Mansour, Pollitt, DeChiara, Kimble, Valenzuela, Yancopoulos, Wilkie: "Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B." in: Nature genetics, Vol. 24, Issue 3, pp. 275-8, 2000
van Bokhoven, Celli, Kayserili, van Beusekom, Balci, Brussel, Skovby, Kerr, Percin, Akarsu, Brunner: "Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome." in: Nature genetics, Vol. 25, Issue 4, pp. 423-6, 2000
Schwabe, Tinschert, Buschow, Meinecke, Wolff, Gillessen-Kaesbach, Oldridge, Wilkie, Kömec, Mundlos: "Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B." in: American journal of human genetics, Vol. 67, Issue 4, pp. 822-31, 2000
Masiakowski, Carroll: "A novel family of cell surface receptors with tyrosine kinase-like domain." in: The Journal of biological chemistry, Vol. 267, Issue 36, pp. 26181-90, 1993
ImagesProduct Details anti-ROR2 Antibody Target Details ROR2 Application Details Handling References for anti-ROR2 antibody (ABIN359932) back to top