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Siglece Products

(Sialic Acid Binding Ig-Like Lectin E (Siglece))

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Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

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Featured Siglece Categories

Siglece Antibodies

High quality antibodies with extensive validation data.

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Recommended Siglece ELISA Kits

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Recommended Siglece Proteins

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Latest Publications for our Siglece products

Smith, Deutzmann, Correa, Delaveris, Dhanasekaran, Dove, Sullivan, Wisnovsky, Stark, Pluvinage, Swaminathan, Riley, Rajan, Majeti, Felsher, Bertozzi: "MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 120, Issue 11, pp. e2215376120, (2023) (PubMed).

Dharmadhikari, Stolz, Hauke, Morgan, Varki, de Koning, Kelm, Maedler: "Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes." in: Scientific reports, Vol. 7, pp. 45319, (2017) (PubMed).

Wu, Ren, Chen: "Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 8, pp. 3336-3347, (2016) (PubMed).

Boyd, Orr, Spence, Burrows, Elliott, Carroll, Brennan, Ní Gabhann, Coulter, Jones, Crocker, Johnston, Jefferies: "Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 12, pp. 7703-9, (2009) (PubMed).

Synonyms and alternative names related to Siglece

sialic acid binding Ig-like lectin E (Siglece), Cd170, mSiglec-E, Siglec5, Siglec9, Siglec12, Siglecl1

Protein level used designations for Siglece

  • MIS
  • SIGLEC-like 1
  • myeloid inhibitory siglec
  • sialic acid binding Ig-like lectin 5
  • sialic acid-binding Ig-like lectin 12
  • sialic acid-binding Ig-like lectin 5
  • sialic acid-binding Ig-like lectin E
  • sialic acid-binding Ig-like lectin-like 1
  • sialic acid-binding immunoglobulin-like lectin E
  • siglec-12
  • siglec-5
  • siglec-E
  • siglec-L1
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