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anti-Human LRP1 Antibodies:
anti-Rat (Rattus) LRP1 Antibodies:
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Human Polyclonal LRP1 Primary Antibody for IHC, WB - ABIN2787740
Hentschke, Poli-de-Figueiredo, da Costa, Kurlak, Williams, Mistry: Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype. in Journal of lipid research 2013
Show all 3 Pubmed References
Human Monoclonal LRP1 Primary Antibody for FACS - ABIN2472830
Moestrup, Gliemann, Pallesen: Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. in Cell and tissue research 1992
Show all 4 Pubmed References
Human Monoclonal LRP1 Primary Antibody for ELISA, FACS - ABIN2472827
Moestrup, Hokland: Surface expression of the alpha 2-macroglobulin receptor on human malignant blood cells. in Leukemia research 1992
Show all 4 Pubmed References
Results indicate that holo-Lf, but not apo (show C9orf3 Antibodies)-Lf, increases TE expression through LRP-1 in human dermal fibroblasts and suggest that holo-Lf and TGF-beta1 (show TGFB1 Antibodies) enhance TE expression by activating the PI3K (show PIK3CA Antibodies)/Akt1 (show AKT1 Antibodies) and PI3K (show PIK3CA Antibodies)/Akt2 (show AKT2 Antibodies) pathways, respectively.
Development of a monoclonal anti-ADAMTS-5 (show ADAMTS5 Antibodies) antibody that specifically blocks the interaction with LRP1.
MMP-13 (show MMP13 Antibodies) may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 is a key modulator of extracellular levels of MMP-13 (show MMP13 Antibodies) and its internalization is independent of the levels of ADAMTS-4 (show ADAMTS4 Antibodies), -5 and TIMP-3 (show TIMP3 Antibodies).
Dissecting the interaction between TIMP3 (show TIMP3 Antibodies) and LRP1 using a synthetic analog of the LRP1 receptor has been reported.
FVIIa-antithrombin (show SERPINC1 Antibodies) but not FVIIa is a ligand for LRP1, and LRP1 contributes to the clearance of FVIIa-antithrombin (show SERPINC1 Antibodies) in vivo
Activated alpha2 -Macroglobulin (show A2M Antibodies) Induces Mesenchymal Cellular Migration Of Raw264.7 Cells Through Low-Density Lipoprotein Receptor-Related Protein 1
Study demonstrated that LRP1 expression is significantly upregulated by myeloid cells in active multiple sclerosis lesions in comparison to the surrounding healthy tissue. Results suggest that the function of LRP1 in microglia is to keep these cells in an anti-inflammatory and neuroprotective status during inflammatory insult.
Poor LRP1 expression in T cells depends on shedding. Integrin ligands and CXCL12 (show CXCL12 Antibodies) antagonize shedding through a TSP-1 (show THBS1 Antibodies)-dependent pathway and ligation of CD28 (show CD28 Antibodies) antagonizes shedding independent of TSP-1 (show THBS1 Antibodies).
Altered Met receptor phosphorylation and LRP1-mediated uptake in cells lacking carbohydrate-dependent lysosomal targeting
LRP1 single-nucleotide polymorphism is associated with migraine.
Results suggest that LRP1 facilitates NSPCs differentiation via interaction with apolipoprotein E (ApoE (show APOE Antibodies)). Upon ApoE4 stimulation wild type neural stem/progenitor cells generated more oligodendrocytes, but LRP1 knockout cells showed no response. The effect of ApoE (show APOE Antibodies) seems to be independent of cholesterol uptake, but is rather mediated by downstream MAPK (show MAPK1 Antibodies) and Akt (show AKT1 Antibodies) activation.
Data suggest that Lrp1 shedding from microglia of cerebral cortex may amplify and sustain neuroinflammation in response to proinflammatory stimuli.
both LRP1 and LDLR (show LDLR Antibodies) expression and agLDL uptake are regulated by P2Y2R (show P2RY2 Antibodies) in vascular smooth muscle cells, and agLDL uptake due to P2Y2R (show P2RY2 Antibodies) activation is dependent upon cytoskeletal reorganization mediated by P2Y2R (show P2RY2 Antibodies) binding to FLN-A (show FLNA Antibodies)
In experimental autoimmune encephalomyelitis mice lacking LRP1 in microglia or in macrophages, only microglial LRP1 was protective, as animals lacking LRP1 in this compartment experienced a worse clinical outcome. Results suggest that the function of LRP1 in microglia is to keep these cells in an anti-inflammatory and neuroprotective status during inflammatory insult, including experimental autoimmune encephalomyelitis.
Therefore, we concluded that the beneficial effects of LF might be due to an increase of autophagy activity via AMPK (show PRKAA1 Antibodies) signaling through the LRP1 receptor. These findings provide a novel insight into the physiological role of LF for the maintenance of cellular and tissue homeostasis.
This study demonstrated that LRP1 suppresses microglial activation by modulating JNK (show MAPK8 Antibodies) and NF-kappaB (show NFKB1 Antibodies) signaling pathways. Down-regulation of LRP1 levels and the increased pro-inflammatory signaling may result in a vicious cycle, in which the two events synergistically promote microglial activation
ApoC-III (show APOC3 Antibodies) inhibits turnover of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR (show LDLR Antibodies)/LRP1 axis
These results provide evidence supporting a key role for the p38 MAPK (show MAPK14 Antibodies) signaling pathway which is involved in the regulation of Abeta1-42 internalization in the parietal cortex and hippocampus of mouse through LRP1 in vivo.
BMPER (show BMPER Antibodies)/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response.
Even though LRP-1 mRNA and protein levels were dramatically reduced in LRP-1-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1-silenced and mock-silenced cultures.
Hypoxia increases LRP1 expression and that LRP1 overexpression mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes.
Endometrial LRP1 protein expression was specifically high in such cyclic and pregnancy stages.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
, TbetaR-V/LRP-1/IGFBP-3 receptor
, alpha-2-macroglobulin receptor
, apolipoprotein E receptor
, prolow-density lipoprotein receptor-related protein 1
, type V tgf-beta receptor
, low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
, low density lipoprotein receptor-related protein 1
, prolow-density lipoprotein receptor-related protein 1-like
, alpha 2-macroglobulin receptor
, lipoprotein receptor-related protein
, low-density lipoprotein receptor-related protein 1
, low-density lipoprotein receptor-related protein/alpha-2 macroglobulin receptor
, LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1