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anti-Human LRP1 Antibodies:
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Human Polyclonal LRP1 Primary Antibody for IHC, WB - ABIN2787740
Hentschke, Poli-de-Figueiredo, da Costa, Kurlak, Williams, Mistry: Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype. in Journal of lipid research 2013
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Human Monoclonal LRP1 Primary Antibody for ELISA, FACS - ABIN2472827
Moestrup, Gliemann, Pallesen: Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. in Cell and tissue research 1992
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Human Monoclonal LRP1 Primary Antibody for FACS - ABIN2472830
Moestrup, Hokland: Surface expression of the alpha 2-macroglobulin receptor on human malignant blood cells. in Leukemia research 1992
Show all 4 Pubmed References
Association of low-density lipoprotein receptor-related protein 1 rs11613352 and angiopoietin-like 3 rs2131925 with hypertension might imply a direct effect at the artery wall.
The results presented in this study raise the hypothesis that higher production of LRP1 protein may be associated with higher endocytosis of upregulated transporter proteins at the cell surface, and hence, increased dox and emodin accumulation and growth inhibition. If so, elevation of LRP1 expression may be a useful target for interventions to promote the efficacy of these and other anticancer drugs.
This study is the first to determine that the sLR11 gene rs3824968 polymorphic of factor T may increase the risk of carotid atherosclerosis in Type 2 Diabetes Mellitus patients by regulating the concentration of LDL-C in Korean and Han nationalities in China
A common polymorphism decreases LRP1 mRNA stability and is associated with increased plasma factor VIII levels.
circulating sLRP1 is a novel surrogate biomarker of EAT volume in T1DM patients.
Data show that amyloid precursor protein (APP) dimerization affects its interaction with LDL receptor related protein 1 (LRP1) and LDL-receptor related protein SorLA (SorLA), suggesting that APP dimerization modulates its interplay with sorting molecules and in turn its localization and processing.
LRP1 mediates cell adhesion by orchestrating a multi-protein pathway to activate, traffic and degrade integrins. Thus, LRP1 may serve as a focal point in the integrin quality control system to ensure a firm connection to the extracellular matrix.
This study defines LRP1 as a regulator of CXCR3, which may have important consequences for tumor biology.
The C4408R mutant located at the APP695 alpha-secretase cleavage site of LRP1, when expressed in CHO cells expressing APPswe or wild-type APP (APPwt), co-expression of LRP1-CT C4408R decreases Abeta and increases sAPPalpha and alpha-CTF compared with co-expression of wild-type LRP1-CT. LRP1-CT C4408R enhanced the unglycosylated form of LRP1-CT and reduced APP endocytosis.
In cerebral blood vessels, LRP1 is an important mediator for the rapid removal of ABETA from brain via transport across the blood-brain barrier. This work summarizes recent findings on LRP1 function and discuss the targeting of LRP1 as a modulator for Alzheimer's Disease pathology and drug delivery into the brain. [review]
Extracellular vesicles do not contribute to higher circulating levels of soluble LRP1 in idiopathic dilated cardiomyopathy.
LRP-1 silencing leads to a decrease of cell migratory capacity in a 3D configuration.
LRP1 has a role in insulin signaling and is a potential role as a link between lipoprotein and glucose metabolism in diabetes [review]
Results indicate that holo-Lf, but not apo-Lf, increases TE expression through LRP-1 in human dermal fibroblasts and suggest that holo-Lf and TGF-beta1 enhance TE expression by activating the PI3K/Akt1 and PI3K/Akt2 pathways, respectively.
Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.
MMP-13 may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 is a key modulator of extracellular levels of MMP-13 and its internalization is independent of the levels of ADAMTS-4, -5 and TIMP-3.
Dissecting the interaction between TIMP3 and LRP1 using a synthetic analog of the LRP1 receptor has been reported.
FVIIa-antithrombin but not FVIIa is a ligand for LRP1, and LRP1 contributes to the clearance of FVIIa-antithrombin in vivo
Activated alpha2 -Macroglobulin Induces Mesenchymal Cellular Migration Of Raw264.7 Cells Through Low-Density Lipoprotein Receptor-Related Protein 1
Study demonstrated that LRP1 expression is significantly upregulated by myeloid cells in active multiple sclerosis lesions in comparison to the surrounding healthy tissue. Results suggest that the function of LRP1 in microglia is to keep these cells in an anti-inflammatory and neuroprotective status during inflammatory insult.
the intracellular domain of Lrp1 interacts with the nuclear receptor Ppargamma, a central regulator of lipid and glucose metabolism, acting as its transcriptional co-activator in endothelial cells.
Collectively, these studies reveal a novel role for Lrp1 in peroxisome biogenesis, lipid homeostasis, and OPC differentiation during white matter development and repair.
A knockin mouse model was used to uncover a novel atheroprotective role for LRP1 in macrophages where tyrosine phosphorylation of an NPxY motif in its intracellular domain initiates a signaling cascade along an LRP1/SHC1/PI3K/AKT/PPARgamma/LXR axis to regulate and integrate cellular cholesterol homeostasis through the expression of the major cholesterol exporter ABCA1 with apoptotic cell removal and inflammatory respon...
MMP-9 activation by hypoxia requires LRP1 and Pyk2 phosphorylation in fibroblasts.
Results suggest that LRP1 facilitates NSPCs differentiation via interaction with apolipoprotein E (ApoE). Upon ApoE4 stimulation wild type neural stem/progenitor cells generated more oligodendrocytes, but LRP1 knockout cells showed no response. The effect of ApoE seems to be independent of cholesterol uptake, but is rather mediated by downstream MAPK and Akt activation.
Data suggest that Lrp1 shedding from microglia of cerebral cortex may amplify and sustain neuroinflammation in response to proinflammatory stimuli.
both LRP1 and LDLR expression and agLDL uptake are regulated by P2Y2R in vascular smooth muscle cells, and agLDL uptake due to P2Y2R activation is dependent upon cytoskeletal reorganization mediated by P2Y2R binding to FLN-A
In experimental autoimmune encephalomyelitis mice lacking LRP1 in microglia or in macrophages, only microglial LRP1 was protective, as animals lacking LRP1 in this compartment experienced a worse clinical outcome. Results suggest that the function of LRP1 in microglia is to keep these cells in an anti-inflammatory and neuroprotective status during inflammatory insult, including experimental autoimmune encephalomyelitis.
Therefore, we concluded that the beneficial effects of LF might be due to an increase of autophagy activity via AMPK signaling through the LRP1 receptor. These findings provide a novel insight into the physiological role of LF for the maintenance of cellular and tissue homeostasis.
This study demonstrated that LRP1 suppresses microglial activation by modulating JNK and NF-kappaB signaling pathways. Down-regulation of LRP1 levels and the increased pro-inflammatory signaling may result in a vicious cycle, in which the two events synergistically promote microglial activation
ApoC-III inhibits turnover of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR/LRP1 axis
These results provide evidence supporting a key role for the p38 MAPK signaling pathway which is involved in the regulation of Abeta1-42 internalization in the parietal cortex and hippocampus of mouse through LRP1 in vivo.
BMPER/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response.
report that LRP1 expression is rapidly lost as oligodendrocyte progenitor cells differentiate, and is absent from all oligodendrocytes, including newborn oligodendrocytes
Results show evidence of low-density lipoprotein receptor-related protein 1 ( (LRP1) expression and activity modulation by Intravenous immunoglobulin (IVIg), and support the role of LRP1 as a partner of IVIg in the execution of its neuroprotective effects.
LRP1 deficiency in mature adipocytes promotes diet-induced inflammation and atherosclerosis.
TNF-alpha blockade exerts antiatherosclerotic effects that are dependent on the presence of macrophage LRP1.
these results documented that LRP1 deficiency in hepatocytes promotes lipid accumulation and lipotoxicity through lysosomal-mitochondrial permeabilization and ER stress that ultimately result in cell death. Hence, LRP1 dysfunction may be a major risk factor in fatty liver disease progression.
Even though LRP-1 mRNA and protein levels were dramatically reduced in LRP-1-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1-silenced and mock-silenced cultures.
Hypoxia increases LRP1 expression and that LRP1 overexpression mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes.
Endometrial LRP1 protein expression was specifically high in such cyclic and pregnancy stages.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
, TbetaR-V/LRP-1/IGFBP-3 receptor
, alpha-2-macroglobulin receptor
, apolipoprotein E receptor
, prolow-density lipoprotein receptor-related protein 1
, type V tgf-beta receptor
, low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
, low density lipoprotein receptor-related protein 1
, prolow-density lipoprotein receptor-related protein 1-like
, alpha 2-macroglobulin receptor
, lipoprotein receptor-related protein
, low-density lipoprotein receptor-related protein 1
, low-density lipoprotein receptor-related protein/alpha-2 macroglobulin receptor
, LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1