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anti-Human LRP1 Antibodies:
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Human Polyclonal LRP1 Primary Antibody for IHC, WB - ABIN2787740
Hentschke, Poli-de-Figueiredo, da Costa, Kurlak, Williams, Mistry: Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype. in Journal of lipid research 2013
Show all 3 Pubmed References
Human Monoclonal LRP1 Primary Antibody for FACS - ABIN2472830
Moestrup, Gliemann, Pallesen: Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. in Cell and tissue research 1992
Show all 4 Pubmed References
Human Monoclonal LRP1 Primary Antibody for ELISA, FACS - ABIN2472827
Moestrup, Hokland: Surface expression of the alpha 2-macroglobulin receptor on human malignant blood cells. in Leukemia research 1992
Show all 4 Pubmed References
This study defines LRP1 as a regulator of CXCR3 (show CXCR3 Antibodies), which may have important consequences for tumor biology.
The C4408R mutant located at the APP695 alpha-secretase cleavage site of LRP1, when expressed in CHO (show COL11A1 Antibodies) cells expressing APPswe or wild-type APP (show APP Antibodies) (APPwt), co-expression of LRP1-CT C4408R decreases Abeta (show APP Antibodies) and increases sAPPalpha and alpha-CTF (show NFIA Antibodies) compared with co-expression of wild-type LRP1-CT. LRP1-CT C4408R enhanced the unglycosylated form of LRP1-CT and reduced APP (show APP Antibodies) endocytosis.
In cerebral blood vessels, LRP1 is an important mediator for the rapid removal of ABETA (show APP Antibodies) from brain via transport across the blood-brain barrier. This work summarizes recent findings on LRP1 function and discuss the targeting of LRP1 as a modulator for Alzheimer's Disease pathology and drug delivery into the brain. [review]
Extracellular vesicles do not contribute to higher circulating levels of soluble LRP1 in idiopathic dilated cardiomyopathy.
LRP-1 silencing leads to a decrease of cell migratory capacity in a 3D configuration.
LRP1 has a role in insulin (show INS Antibodies) signaling and is a potential role as a link between lipoprotein and glucose metabolism in diabetes [review]
Results indicate that holo-Lf, but not apo (show C9orf3 Antibodies)-Lf, increases TE expression through LRP-1 in human dermal fibroblasts and suggest that holo-Lf and TGF-beta1 (show TGFB1 Antibodies) enhance TE expression by activating the PI3K (show PIK3CA Antibodies)/Akt1 (show AKT1 Antibodies) and PI3K (show PIK3CA Antibodies)/Akt2 (show AKT2 Antibodies) pathways, respectively.
Development of a monoclonal anti-ADAMTS-5 (show ADAMTS5 Antibodies) antibody that specifically blocks the interaction with LRP1.
MMP-13 (show MMP13 Antibodies) may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 is a key modulator of extracellular levels of MMP-13 (show MMP13 Antibodies) and its internalization is independent of the levels of ADAMTS-4 (show ADAMTS4 Antibodies), -5 and TIMP-3 (show TIMP3 Antibodies).
Dissecting the interaction between TIMP3 (show TIMP3 Antibodies) and LRP1 using a synthetic analog of the LRP1 receptor has been reported.
Collectively, these studies reveal a novel role for Lrp1 in peroxisome biogenesis, lipid homeostasis, and OPC differentiation during white matter development and repair.
A knockin mouse model was used to uncover a novel atheroprotective role for LRP1 in macrophages where tyrosine phosphorylation of an NPxY motif in its intracellular domain initiates a signaling cascade along an LRP1/SHC1 (show SHC1 Antibodies)/PI3K/AKT (show AKT1 Antibodies)/PPARgamma (show PPARG Antibodies)/LXR (show NR1H3 Antibodies) axis to regulate and integrate cellular cholesterol homeostasis through the expression of the major cholesterol exporter ABCA1 (show ABCA1 Antibodies) with apoptotic cell removal and inflammatory respon...
MMP-9 (show MMP9 Antibodies) activation by hypoxia requires LRP1 and Pyk2 (show PTK2B Antibodies) phosphorylation in fibroblasts.
Results suggest that LRP1 facilitates NSPCs differentiation via interaction with apolipoprotein E (ApoE (show APOE Antibodies)). Upon ApoE4 stimulation wild type neural stem/progenitor cells generated more oligodendrocytes, but LRP1 knockout cells showed no response. The effect of ApoE (show APOE Antibodies) seems to be independent of cholesterol uptake, but is rather mediated by downstream MAPK (show MAPK1 Antibodies) and Akt (show AKT1 Antibodies) activation.
FVIIa-antithrombin (show SERPINC1 Antibodies) but not FVIIa is a ligand for LRP1, and LRP1 contributes to the clearance of FVIIa-antithrombin (show SERPINC1 Antibodies) in vivo
Data suggest that Lrp1 shedding from microglia of cerebral cortex may amplify and sustain neuroinflammation in response to proinflammatory stimuli.
both LRP1 and LDLR (show LDLR Antibodies) expression and agLDL uptake are regulated by P2Y2R (show P2RY2 Antibodies) in vascular smooth muscle cells, and agLDL uptake due to P2Y2R (show P2RY2 Antibodies) activation is dependent upon cytoskeletal reorganization mediated by P2Y2R (show P2RY2 Antibodies) binding to FLN-A (show FLNA Antibodies)
In experimental autoimmune encephalomyelitis mice lacking LRP1 in microglia or in macrophages, only microglial LRP1 was protective, as animals lacking LRP1 in this compartment experienced a worse clinical outcome. Results suggest that the function of LRP1 in microglia is to keep these cells in an anti-inflammatory and neuroprotective status during inflammatory insult, including experimental autoimmune encephalomyelitis.
Therefore, we concluded that the beneficial effects of LF might be due to an increase of autophagy activity via AMPK (show PRKAA1 Antibodies) signaling through the LRP1 receptor. These findings provide a novel insight into the physiological role of LF for the maintenance of cellular and tissue homeostasis.
This study demonstrated that LRP1 suppresses microglial activation by modulating JNK (show MAPK8 Antibodies) and NF-kappaB (show NFKB1 Antibodies) signaling pathways. Down-regulation of LRP1 levels and the increased pro-inflammatory signaling may result in a vicious cycle, in which the two events synergistically promote microglial activation
Even though LRP-1 mRNA and protein levels were dramatically reduced in LRP-1-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1-silenced and mock-silenced cultures.
Hypoxia increases LRP1 expression and that LRP1 overexpression mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes.
Endometrial LRP1 protein expression was specifically high in such cyclic and pregnancy stages.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
, TbetaR-V/LRP-1/IGFBP-3 receptor
, alpha-2-macroglobulin receptor
, apolipoprotein E receptor
, prolow-density lipoprotein receptor-related protein 1
, type V tgf-beta receptor
, low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
, low density lipoprotein receptor-related protein 1
, prolow-density lipoprotein receptor-related protein 1-like
, alpha 2-macroglobulin receptor
, lipoprotein receptor-related protein
, low-density lipoprotein receptor-related protein 1
, low-density lipoprotein receptor-related protein/alpha-2 macroglobulin receptor
, LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1