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SOX4 Products

(SRY (Sex Determining Region Y)-Box 4 (SOX4))

Categories

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008].

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Featured SOX4 Categories

SOX4 Antibodies

High quality antibodies with extensive validation data.

SOX4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SOX4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet

Application IHC, WB
Validations
  • (13)
Cat. No. ABIN2780469
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application FACS, IF, IHC, ELISA, WB
Validations
  • (6)
Cat. No. ABIN3032699
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, ICC, IF (cc), IF (p), IHC (fro), IHC (p), WB
Validations
  • (5)
Cat. No. ABIN1387237
Quantity 100 μL
Datasheet Datasheet

Recommended SOX4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2732454
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3077076
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3121476
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our SOX4 products

Liu, Wu, Zhou, Cai, Li, Hu, Gao, Feng, Wang, Peng, Qi, Liu, Han: "The SOX4/miR-17-92/RB1 Axis Promotes Prostate Cancer Progression." in: Neoplasia (New York, N.Y.), Vol. 21, Issue 8, pp. 765-776, (2019) (PubMed).

Zhou, Wang, Huang, Chen, Zhao, Yao, Jin, Huang, Liu, Li: "Down-regulated SOX4 expression suppresses cell proliferation, metastasis and induces apoptosis in Xuanwei female lung cancer patients." in: Journal of cellular biochemistry, Vol. 116, Issue 6, pp. 1007-18, (2015) (PubMed).

Koumangoye, Andl, Taubenslag, Zilberman, Taylor, Loomans, Andl: "SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells." in: Molecular cancer, Vol. 14, pp. 24, (2015) (PubMed).

Kato, Bhattaram, Penzo-Méndez, Gadi, Lefebvre: "SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 30, Issue 9, pp. 1560-71, (2015) (PubMed).

Chen, Ruan, Wang, Han, Wang, Lou, Ruan, Qiu, Yang, Zhang: "miR-129-3p, as a diagnostic and prognostic biomarker for renal cell carcinoma, attenuates cell migration and invasion via downregulating multiple metastasis-related genes." in: Journal of cancer research and clinical oncology, Vol. 140, Issue 8, pp. 1295-304, (2014) (PubMed).

Grau, Luque-Garcia, González-Peramato, Theodorescu, Palou, Fernandez-Gomez, Sánchez-Carbayo: "A quantitative proteomic analysis uncovers the relevance of CUL3 in bladder cancer aggressiveness." in: PLoS ONE, Vol. 8, Issue 1, pp. e53328, (2013) (PubMed).

Usui, Mochizuki, Iida, Miyauchi, Satoh, Sock, Nakauchi, Aburatani, Murakami, Wegner, Watanabe: "The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells." in: Development (Cambridge, England), Vol. 140, Issue 4, pp. 740-50, (2013) (PubMed).

Medina, Castillo, Blanco, Sanz-Garcia, Largo, Alvarez, Yokota, Gonzalez-Neira, Benitez, Clevers, Cigudosa, Lazo, Sanchez-Cespedes: "The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer." in: Human molecular genetics, Vol. 18, Issue 7, pp. 1343-52, (2009) (PubMed).

Ruebel, Leontovich, Tanizaki, Jin, Stilling, Zhang, Coonse, Scheithauer, Lombardero, Kovacs, Lloyd: "Effects of TGFbeta1 on gene expression in the HP75 human pituitary tumor cell line identified by gene expression profiling." in: Endocrine, Vol. 33, Issue 1, pp. 62-76, (2008) (PubMed).

Synonyms and alternative names related to SOX4

SRY-box 4 (SOX4), SRY box 4 (Sox4), SRY (sex determining region Y)-box 4 (Sox4), SRY (sex determining region Y)-box 4a (sox4a), AA682046, EVI16, Sox-4, sox4, wu:fb82f08, wu:fq41g10, zgc:65850, zgc:77392

Protein level used designations for SOX4

  • SRY-box containing protein 4
  • transcription factor SOX-4
  • SRY-related HMG-box gene 4
  • ecotropic viral integration site 16
  • SRY-box containing gene 4
  • SRY (sex determining region Y)-box 4
  • SRY (sex determining region Y)-box 4a
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