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SP100 Products

(SP100 Nuclear Antigen (SP100))

Categories

This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene\; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011].

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Featured SP100 Categories

SP100 Antibodies

High quality antibodies with extensive validation data.

SP100 ELISA Kits

Reliable ELISA kits for a wide range of species.

SP100 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SP100 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application RNAi, ELISA, WB
Validations
  • (1)
  • (4)
Cat. No. ABIN562971
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IHC (p), WB
Validations
  • (3)
  • (3)
Cat. No. ABIN948494
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, ICC, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN6257499
Quantity 100 μL
Datasheet Datasheet

Recommended SP100 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN1117209
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN511609
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN773774
Quantity 96 tests
Datasheet Datasheet

Recommended SP100 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3131693
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095562
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321021
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our SP100 products

Niu, Livingston, Li, Beran, Daffis, Ramakrishnan, Burdette, Peiser, Salas, Ramos, Yu, Cheng, Strubin, Delaney Iv, Fletcher: "The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection." in: PLoS ONE, Vol. 12, Issue 1, pp. e0169648, (2017) (PubMed).

Berard, Coombs, Severini: "Quantification of the host response proteome after herpes simplex virus type 1 infection." in: Journal of proteome research, Vol. 14, Issue 5, pp. 2121-42, (2015) (PubMed).

Wagenknecht, Reuter, Scherer, Reichel, Müller, Stamminger: "Contribution of the Major ND10 Proteins PML, hDaxx and Sp100 to the Regulation of Human Cytomegalovirus Latency and Lytic Replication in the Monocytic Cell Line THP-1." in: Viruses, Vol. 7, Issue 6, pp. 2884-907, (2015) (PubMed).

Full, Jungnickl, Reuter, Bogner, Brulois, Scholz, Stürzl, Myoung, Jung, Stamminger, Ensser: "Kaposi's sarcoma associated herpesvirus tegument protein ORF75 is essential for viral lytic replication and plays a critical role in the antagonization of ND10-instituted intrinsic immunity." in: PLoS pathogens, Vol. 10, Issue 1, pp. e1003863, (2014) (PubMed).

Stepp, Meyers, McBride: "Sp100 provides intrinsic immunity against human papillomavirus infection." in: mBio, Vol. 4, Issue 6, pp. e00845-13, (2013) (PubMed).

Adler, Tavalai, Müller, Stamminger: "Human cytomegalovirus immediate-early gene expression is restricted by the nuclear domain 10 component Sp100." in: The Journal of general virology, Vol. 92, Issue Pt 7, pp. 1532-8, (2011) (PubMed).

Tavalai, Adler, Scherer, Riedl, Stamminger: "Evidence for a dual antiviral role of the major nuclear domain 10 component Sp100 during the immediate-early and late phases of the human cytomegalovirus replication cycle." in: Journal of virology, Vol. 85, Issue 18, pp. 9447-58, (2011) (PubMed).

Synonyms and alternative names related to SP100

SP100 nuclear antigen (SP100), nuclear antigen Sp100 (Sp100), SP100 nuclear antigen (Sp100), nuclear autoantigen Sp-100 (LOC101120993), A430075G10Rik, lysp100b, SP100, SP140

Protein level used designations for SP100

  • SP100 nuclear antigen
  • nuclear autoantigen Sp-100
  • nuclear autoantigen Sp-100-like
  • nuclear dot-associated Sp100 protein
  • speckled 100 kDa
  • SP100-HMG nuclear autoantigen
  • nuclear antigen Sp100
  • Nuclear autoantigen Sp-100
  • SP140 nuclear body protein
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