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anti-Human COMT Antibodies:
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Human Monoclonal COMT Primary Antibody for WB - ABIN1882224
Zeng, Ye, Lu, Chua, Tan, Zhong: Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes. in Organic letters 2010
Show all 5 Pubmed References
Human Polyclonal COMT Primary Antibody for ELISA, WB - ABIN250484
Yao, Harris, Zhang: Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase 2 pathway. in Hypertension (Dallas, Tex. : 1979) 2009
Show all 3 Pubmed References
Human Polyclonal COMT Primary Antibody for ELISA, WB - ABIN547726
Tunbridge, Harrison, Weinberger: Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. in Biological psychiatry 2006
Human Polyclonal COMT Primary Antibody for IHC, IHC (p) - ABIN4299996
Hirata, Hinoda, Okayama, Suehiro, Kawamoto, Kikuno, Rabban, Chen, Dahiya: COMT polymorphisms affecting protein expression are risk factors for endometrial cancer. in Molecular carcinogenesis 2008
Human Polyclonal COMT Primary Antibody for ELISA, ICC - ABIN6258028
Bai, Tang, Zou, Meng, Tu, Xia, Cheng, Zhang, Yang, Mu, Wang, Qin, Lv, Cao, Qin, Jiang, Chen: m6A demethylase FTO regulates dopaminergic neurotransmission deficits caused by arsenite. in Toxicological sciences : an official journal of the Society of Toxicology 2018
Human Polyclonal COMT Primary Antibody for WB - ABIN514522
Hevir, Sinkovec, Rižner: Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT. in Molecular and cellular endocrinology 2010
Variation in the COMT Val108/158Met polymorphism is associated with differential expression of fast sleep spindles in healthy participants.
After controlling for gender, age, and SES, the three-way interaction of COMT, DAT1, and peer acceptance significantly concurrently predicted adolescent depressive symptoms. Adolescents with ValVal genotype of COMT and CC genotype of DAT1 were more sensitive to acceptance
A meta-analysis of DRD4 exon III variable number of tandem repeat (VNTR) and COMT Val158Met association with novelty seeking behavior showed no association was found between the COMT polymorphism and novelty-seeking. Our results regarding COMT are consistent with those of previous published meta-analysis.
Three investigated SNPs were rs165599, rs3737597, and rs1047631 of COMT, DISC1, and DTNBP1, respectively. Our results suggested that rs3737597 showed a significant association with schizophrenia in Europeans (odds ratio: 1.584, P: 0.002, 95% confidence interval: 1.176-2.134) under a random-effect framework. No other associations were found.
There was no significant genotypic association between rs4680 and clinical symptoms or cognitive function in Han Chinese patients with schizophrenia. Patients with GG at rs165599 scored significantly higher on the Stroop test, suggesting better cognitive performance after 8 weeks of treatment. The findings suggest that the COMT gene polymorphisms may influence the response to antipsychotic treatment.
These findings suggest that the association between COMT polymorphisms and cognitive functioning could be, at least in part, due to their association with varying levels of S-COMT. This is important as, unlike MB-COMT, the substrates targeted by S-COMT are likely to be intra-cellular rather than, like dopamine, located mainly in the synaptic vesicles or the extra-cellular space.
The COMT gene rs165599 SNP does not appear to be a single-risk factor for schizophrenia.
An interaction between the COMT genotype and childhood adversity, affects executive function in adolescents.
that the presence of one or two Met alleles of the COMT Val(158/108)Met might act as a protective variant in working memory tasks in combat exposed veterans with posttraumatic stress disorder
Association between COMT Val158Met polymorphisms with antisaccade task performance in schizophrenic patients.
variant and temporomandibular disorders may contribute to individual variation in electric and cold pulp sensitivity
T-77C and Arg399Gln polymorphisms of the XRCC1 gene, as well as the 186C>T and Val158Met polymorphisms of the COMT gene, increased the risk of lung cancer in non-smoking women.
COMT-GG and NRG1-AA genotypes aid the transcranial direct current stimulation-induced improvement in auditory verbal hallucinations in schizophrenia patients.
In those who had used cannabis before 20 years of age, COMT Val158Met polymorphism had a trend level effect on age of onset of psychosis (median age of onset of psychosis : Val/Val < Val/Met < Met/Met 19.37, 20.95, 21.24 years, respectively; log-rank test p = .051).
findings support the hypothesis that G x E interactions underlie associations of COMT val158met with fear inhibition deficits
COMT gene moderates the relation between maternal history of maltreatment and infant emotion regulation.
Its single-nucleotide polymorphisms involves in dopaminergic metabolism and motor and cognitive function in older adults.
COMT DNA methylation level is affected by the severity of the clinical symptoms of schizophrenia and might also be influenced by pharmacological treatment.
The present study showed that females with middle dopamine availability (valA/valB or met/met) and evidence of emotional problems in adolescence were more likely to have affective symptoms at age 53.
findings suggest that Val/Val homozygous individuals for catachol-O-methyltransferase (COMT) may be more flexible regarding self-attribution/body ownership and that biological factors may contribute to reduced awareness regarding the distinction between self and others.
Miroestrol restored uterine COMT expression in beta-naphthoflavone-treated mice.
This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC) and postero-parieto-temporal cortex of male, but not female adult mice.
COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.
COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function
These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1.
The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.
Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.
COMT knockout mice were more impulsive compared with wild-type littermates.
Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.
decreased COMT activity was associated with some changes in feeding microstructure in rats and mice
This study demonistrated that COMT deletion with elevated anxiety in females and suggest that this may be related to a heightened neuroendocrine response to acute stress in COMT KO mice.
COMT deficiency in virgin female mice with intact endogenous production of estradiol results in relative protection against atherosclerosis
In catechol-O-methyltransferase knock-out mice administration of tetrahydrocannabinol induced a larger increase in exploratory behavior and greater impairment in spatial working memory.
Strains with the SINE haplotype (+SINE) have greater Comt1 enzymatic activity. +SINE mice also exhibit behavioral differences in anxiety assays and decreased pain sensitivity.
Findings show that Comt1(B2i) (a B2 SINE insertion) results in a relatively modest difference in Comt1 expression and enzyme activity which has a demonstrable behavioral effect across a variety of outbred genetic backgrounds.
the source of variation in Comt
A lack of S-COMT has a notable brain-area and sex-dependent effect on the O-methylation of dopamine and 3,4-dihydroxyphenylacetic acid in the mouse brain and induces subtle change in social behavior and nociception
In the mouse, the prefrontal cortex COMT contributes about one half of the total dopamine clearance.
Both soluble COMT and membrane-bound COMT forms were abundantly found in microglial cells and intestinal macrophages, but also in astroglial cells. COMT was also present in some neuronal cells and nuclear COMT is not visible in S-COMT deficient mice.
Findings in mice with reduced or absent COMT activity reveal its important role in the dopamine-mediated regulation of renal sodium excretion.
An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
, catechol-O-methyltransferase 1
, catechol O-methyltransferase, soluble form
, catechol O-methyltransferase, membrane-bound form