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anti-Human COMT Antibodies:
anti-Mouse (Murine) COMT Antibodies:
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Human Monoclonal COMT Primary Antibody for WB - ABIN1882224
Zeng, Ye, Lu, Chua, Tan, Zhong: Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes. in Organic letters 2010
Show all 5 Pubmed References
Human Polyclonal COMT Primary Antibody for ELISA, WB - ABIN250484
Yao, Harris, Zhang: Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase 2 pathway. in Hypertension (Dallas, Tex. : 1979) 2009
Show all 3 Pubmed References
Human Polyclonal COMT Primary Antibody for IHC, IHC (p) - ABIN4299996
Hirata, Hinoda, Okayama, Suehiro, Kawamoto, Kikuno, Rabban, Chen, Dahiya: COMT polymorphisms affecting protein expression are risk factors for endometrial cancer. in Molecular carcinogenesis 2008
Human Polyclonal COMT Primary Antibody for EIA, ELISA - ABIN188559
Tunbridge, Harrison, Weinberger: Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. in Biological psychiatry 2006
Human Polyclonal COMT Primary Antibody for WB - ABIN514522
Hevir, Sinkovec, Rižner: Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT. in Molecular and cellular endocrinology 2010
No significant difference was observed in the RNA levels of CYP1A1 (show CYP1A1 Antibodies) and SULT1A1 (show SULT1A1 Antibodies) between the two groups. The frequency of expression of the CYP17 (show CYP17A1 Antibodies) T/C variant tended to be higher and the A allele of COMT polymorphism together with down-regulation of its mRNA expression may be more frequent in Chinese women with idiopathic POI
Individuals carrying Val/Val of COMT seem to be more sensitive to the synergistic effect of environmental factors acting early in neurodevelopment.
childhood urbanicity and variation in dopamine genes COMT, DRD1 (show DRD1 Antibodies) and DRD2 (show DRD2 Antibodies) alters adult prefrontal function as measured by fMRI
the association between the COMT Val158Met and ZDHHC8 (show ZDHHC8 Antibodies) rs175174 single nucleotide polymorphism and the susceptibility to schizophrenia through a case-control study involving a population from the North Region of Brazil, was investigated.
Results revealed a sex-specific effect of COMT on corpus callosum (CC): in males only, Val homozygotes had significantly higher fractional anisotropy (FA) compared to Met-carriers. Volume-of-interest analysis showed a genotype by sex interaction on FA in genu and rostral midbody of CC, whereby Val males demonstrated higher FA than Met females.
No association between self-reported non-recovery or pain levels and COMT haplotypes in in a Northern European patients with acute whiplash injuries could be detected.
The aim of this study was to investigate the effects of the interaction between the CYP (show PPIG Antibodies) 2A6 and COMT genes on smoking behavior in young Taiwanese men. The odds ratio for starting smoking was significantly lower in subjects carrying a CYP2A6 (show CYP2A6 Antibodies) low activity/variant COMT rs4680 genotype than in those possessing a CYP2A6 (show CYP2A6 Antibodies) wild-type/variant COMT rs4680 genotype (0.44, 95% confidence interval = 0.19-0.98, P = 0.043).
Results show no association between TPMT (show TPMT Antibodies) or COMT single-nucleotide polymorphisms and cisplatin-induced ototoxicity.
Study applied graph theory analysis on resting-state fMRI of 120 women selected based on neuroticism score, & genotyped 2 polymorphisms: 5-HTTLPR (show SLC6A4 Antibodies) (S-carriers and L-homozygotes) and COMT (rs4680-rs165599; COMT risk group and COMT non-risk group). The COMT polymorphism moderated the association between neuroticism and functional network organization.
The purpose of the current study is to test the interaction between prenatal maternal smoking and COMT Val(158)Met in conduct problems and crime in the 1993 Pelotas Birth Cohort Study.
Miroestrol restored uterine COMT expression in beta-naphthoflavone-treated mice.
This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC (show CFP Antibodies)) and postero-parieto-temporal cortex of male, but not female adult mice.
COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.
COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function
These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1 (show DTNBP1 Antibodies).
The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.
Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.
COMT knockout mice were more impulsive compared with wild-type littermates.
Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.
decreased COMT activity was associated with some changes in feeding microstructure in rats and mice
An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
, catechol-O-methyltransferase 1
, catechol O-methyltransferase, soluble form
, catechol O-methyltransferase, membrane-bound form