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|Antigen||Interferon Regulatory Factor 4 (IRF4) Antibodies|
|Conjugate||This IRF4 antibody is un-conjugated Alternatives|
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|2 references available|
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Product Details anti-IRF4 AntibodyTarget Details IRF4 Application Details Handling References for anti-IRF4 antibody (ABIN115258) Images
Reacts to MUM1 Protein.
Cellular Localization: Nuclear and cytoplasmic
|Immunogen||Recombinant GST-MUM1 protein|
Target Details IRF4Product Details anti-IRF4 Antibody Application Details Handling References for anti-IRF4 antibody (ABIN115258) Images back to top
|Alternative Name||IRF4 (IRF4 Antibody Abstract)|
|Background||Multiple myeloma oncogene-1 (MUM1) is a 50kD protein encoded by the MUM1 gene. MUM1 is expressed in a subset of B cells in the light zone of the germinal center, plasma cells, activated T cells and a wide spectrum of related hematolymphoid neoplasms. This antibody is useful in the sub classification of lymphoid malignancies.Synonyms: Interferon regulatory factor 4, LSIRF, Lymphocyte-specific interferon regulatory factor, MUM1, Multiple myeloma oncogene 1, NF-EM5|
Application DetailsProduct Details anti-IRF4 Antibody Target Details IRF4 Handling References for anti-IRF4 antibody (ABIN115258) Images back to top
Immunohistochemistry on Frozen and Formalin-Fixed Paraffin Embedded Sections (Hightemperature treatment of formalin-fixed tissue sections with 1 mM EDTA buffer, pH 9.0must be performed prior to the immunostaining): diluted of 1: 10-1: 25 in an ABC method(30-60 minutes at room temperature). Recommended Positive Control: Tonsil.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IRF4 Antibody Target Details IRF4 Application Details References for anti-IRF4 antibody (ABIN115258) Images back to top
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-IRF4 antibody (ABIN115258)Product Details anti-IRF4 Antibody Target Details IRF4 Application Details Handling Images back to top
Natkunam, Warnke, Montgomery, Falini, van De Rijn: "Analysis of MUM1/IRF4 protein expression using tissue microarrays and immunohistochemistry." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 14, Issue 7, pp. 686-94, 2001
Gaidano, Carbone: "MUM1: a step ahead toward the understanding of lymphoma histogenesis." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 14, Issue 4, pp. 563-6, 2000