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|Antigen||Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1) Antibodies|
|Epitope||AA 701-808 Alternatives|
|Conjugate||This MALT1 antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
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Product Details anti-MALT1 AntibodyTarget Details MALT1 Application Details Handling Images
|Purification||Protein G purified monoclonal antibody|
|Immunogen||A recombinant fragment (aa 701-808) was used as the immunogen for this antibody.|
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|Alternative Name||MALT1 (MALT1 Antibody Abstract)|
|Background||Mucosa associated lymphoid tissue lymphoma translocation gene 1 is found in extranodal low-grade B cell lymphomas. It encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of the MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11,18)(q21,q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear < a href=../search_result.php?search_txt=bcl10>Bcl10, which mediates the oligomerization and activation of a caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.|
|Research Area||Signaling, Apoptosis/Necrosis|
|Pathways||TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response|
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The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.
1. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
|Restrictions||For Research Use only|
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|Buffer||0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C,-20 °C|
|Storage Comment||Store the MALT1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).|
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