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|Antigen||Transforming Growth Factor, beta 1 (TGFB1) Antibodies|
|Epitope||AA 286-293 Alternatives|
|Reactivity||Human, Mammalian, Rabbit Alternatives|
|Conjugate||This TGFB1 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-TGFB1 AntibodyTarget Details TGFB1 Application Details Handling Images
|Specificity||This antibody is specific to TGF-beta-1 (TGFB1)|
Species reactivity (expected):Mammal and Rabbit.
Species reactivity (tested):Human.
|Immunogen||KLH conjugated Synthetic Peptide corresponding to aa 286-293 (of 390) of full-length (including signal peptide) precursor TGFb protein. Genename: TGFB1|
Target Details TGFB1Product Details anti-TGFB1 Antibody Application Details Handling Images back to top
|Alternative Name||TGFB1 (TGFB1 Antibody Abstract)|
|Background||TGF-beta-1 is a multifunctional cytokine that belongs to a superfamily of structurally related regulatory proteins, which includes three mammalian TGF-beta isoforms (TGF-beta-1, -beta-2, and -beta-3), activin/inhibins and bone morphogenetic proteins. The most abundant isoform, TGF-beta-1, is a 25 kDa homodimer composed of two 12.5 kDa subunits joined by disulfide bonds. TGF-beta-1 is a highly conserved molecule - the amino acid sequence between human and mouse differ only by one residue. Although originally defined by its ability to cause anchorage independent cell growth and changes in cell morphology of rat fibroblasts, subsequent research has revealed that TGF-beta is actually a major growth inhibitor for most cell types. It is produced by a wide variety of cell and tissue types during all stages of cell differentiation. TGF-beta-1 sources include platelets, bone and soft tissues such as placenta and kidneys.Synonyms: TGF-beta-1, TGFB, Transforming growth factor beta-1|
|Pathways||EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy|
Application DetailsProduct Details anti-TGFB1 Antibody Target Details TGFB1 Handling Images back to top
ELISA: 1/2000-1/10000. Western Blot: 1/200-1/1000. Immunofluorescence. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TGFB1 Antibody Target Details TGFB1 Application Details Images back to top
|Buffer||0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
ImagesProduct Details anti-TGFB1 Antibody Target Details TGFB1 Application Details Handling back to top