anti-Human Interferon Regulatory Factor 3 antibody for Biochemical Assay

Recommended Interferon Regulatory Factor 3 Antibody (supplied by: Log in to see )

Antigen
Interferon Regulatory Factor 3 (IRF3) Antibodies
  • irf3
  • IRF3
  • C920001K05Rik
  • IRF-3
  • interferon regulatory factor 3
  • interferon regulatory factor 7
  • irf3
  • IRF3
  • irf-3
  • Irf3
  • IRF7
Reactivity
Human, Mouse (Murine)
289
121
71
7
6
6
3
2
2
1
1
1
1
Host
Mouse
257
62
3
Clonality
Monoclonal
Conjugate
Un-conjugated
7
6
6
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Biochemical Assay (BCA)
267
129
103
77
50
41
28
26
25
14
14
8
3
3
3
2
2
1
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Catalog No. ABIN2666278
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
4 ABIN2665204 BCA Mouse IgG1 Log in to see SL-12 4
1 ABIN2665205 BCA Mouse IgG1 Log in to see SL-12 4
1 ABIN2666279 BCA Mouse IgG2b kappa Log in to see 12A4A35 3

General

Antigen Interferon Regulatory Factor 3 (IRF3) Antibodies
Reactivity Human, Mouse (Murine)
(289), (121), (71), (7), (6), (6), (3), (2), (2), (1), (1), (1), (1)
Host Mouse
(257), (62), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate Un-conjugated
(7), (6), (6), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Application Biochemical Assay (BCA)
(267), (129), (103), (77), (50), (41), (28), (26), (25), (14), (14), (8), (3), (3), (3), (2), (2), (1)
Pubmed 3 references available
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Product details

Target Details Application Details Handling References Images
Purification Affinity purified
Clone 12A4A35
Isotype IgG2b kappa

Target Details

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Antigen
Alternative Name IRF3 (IRF3 Antibody Abstract)
Background IRF-3 is a member of the interferon regulatory transcription factor (IRF) family. It mediates interferon-stimulated response element (ISRE) promoter activation and functions as a molecular switch for antiviral activity. DsRNA generated during the course of a viral infection leads to IRF-3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB protein binding to dsRNA-activated factor 1, a complex which activates the transcription of genes under control of ISRE. The phosphorylated IRF-3 is under negative regulation by ubiquitin-mediated degradation. Research indicates that it plays a critical role in stimulated TLR-mediated IL-27 p28 gene expression.
Pathways TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades

Application Details

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Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

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Concentration 0.5 mg/mL
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Upon receipt, store undiluted between 2°C and 8°C.

References

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Background publications

Molle, Goldman, Goriely: "Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 4, pp. 1784-92, 2010

Hiscott: "Triggering the innate antiviral response through IRF-3 activation." in: The Journal of biological chemistry, Vol. 282, Issue 21, pp. 15325-9, 2007

Lin, Heylbroeck, Genin, Pitha, Hiscott: "Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription." in: Molecular and cellular biology, Vol. 19, Issue 2, pp. 959-66, 1999

Images

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Supplier Images
Immunofluorescence (IF) image for anti-Interferon Regulatory Factor 3 (IRF3) antibody (ABIN2666278) anti-Interferon Regulatory Factor 3 (IRF3) antibody
Western Blotting (WB) image for anti-Interferon Regulatory Factor 3 (IRF3) antibody (ABIN2666278) anti-Interferon Regulatory Factor 3 (IRF3) antibody (Image 2)