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|Antigen||Interferon Regulatory Factor 5 (IRF5) Antibodies|
|Epitope||AA 176-240 Alternatives|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This IRF5 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
|3 references available|
|Supplier||Log in to see|
Product Details anti-IRF5 AntibodyTarget Details IRF5 Application Details Handling References for anti-IRF5 antibody (ABIN121152) Images
|Specificity||The antibody recognizes Human and Mouse Interferon Regulatory Factor 5 (IRF-5). Other species not tested.|
|Purification||Protein-G affinity chromatography|
|Immunogen||Recombinant human IRF-5 (176-240 aa) purified from E. coli|
|Plasmids, Primers & others|
Target Details IRF5Product Details anti-IRF5 Antibody Application Details Handling References for anti-IRF5 antibody (ABIN121152) Images back to top
|Alternative Name||IRF5 (IRF5 Antibody Abstract)|
|Background||IRF-5 is a member of IRF family, which plays a critical role in the regulation of genes induced by viral infection, immunostimulation and cell growth regulation. The expression of IRF-5 is limited to lymphoid organs, dendritic cells, and peripheral blood lymphocytes, but is not expressed in numerous leukemia and lymphoma cell lines. Three IRFs(IRF-3, IRF-5, IRF-7) function as direct transducers of virus-mediated signaling and play a critical role in the expression of type I interferon genes and some chemokines.Synonyms: IRF-5, Interferon regulatory factor 5|
|Pathways||TLR Signaling, Autophagy|
Application DetailsProduct Details anti-IRF5 Antibody Target Details IRF5 Handling References for anti-IRF5 antibody (ABIN121152) Images back to top
ELISA. Western blot (1/500 - 1/1,000). Immunoprecipitation. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IRF5 Antibody Target Details IRF5 Application Details References for anti-IRF5 antibody (ABIN121152) Images back to top
|Buffer||PBS, pH 7.4, 0.09 % Sodium Azide|
|Precaution of Use||This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
|Expiry Date||12 months|
References for anti-IRF5 antibody (ABIN121152)Product Details anti-IRF5 Antibody Target Details IRF5 Application Details Handling Images back to top
Ning, Huye, Pagano: "Interferon regulatory factor 5 represses expression of the Epstein-Barr virus oncoprotein LMP1: braking of the IRF7/LMP1 regulatory circuit." in: Journal of virology, Vol. 79, Issue 18, pp. 11671-6, 2005
Barnes, Kellum, Pinder, Frisancho, Pitha: "Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death." in: Cancer research, Vol. 63, Issue 19, pp. 6424-31, 2003
Barnes, Moore, Pitha: "Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 23382-90, 2001
ImagesProduct Details anti-IRF5 Antibody Target Details IRF5 Application Details Handling References for anti-IRF5 antibody (ABIN121152) back to top