anti-Human LBP antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended LBP Antibody (supplied by: Log in to see )

Antigen
Lipopolysaccharide Binding Protein (LBP) Antibodies
  • BPIFD2
  • Bpifd2
  • Ly88
  • LPSBP
  • LBP
  • lipopolysaccharide binding protein
  • lipopolysaccharide-binding protein
  • LBP
  • Lbp
  • LOC100472839
Reactivity
Human
82
63
29
11
9
7
4
3
3
2
2
1
Host
Mouse
83
35
27
3
Clonality
Monoclonal
Conjugate
This LBP antibody is un-conjugated
8
4
2
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
102
72
43
27
18
17
9
9
5
5
4
3
3
3
2
2
2
1
1
1
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Catalog No. ABIN343175
$ 379.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
18.755764 ABIN2856048 IHC (p) WB Rabbit IgG Center Log in to see Polyclonal 0
12.755764 ABIN5622094 IHC (p) WB Rabbit IgG Log in to see Polyclonal 0
10 ABIN1492586 IHC IHC (p) WB Rabbit IgG AA 401-450 Log in to see Polyclonal 0
4 ABIN5582419 IHC (p) Rabbit IgG Log in to see Polyclonal 0
1 ABIN1833157 IHC IHC (p) WB Rabbit IgG AA 166-467 Log in to see Polyclonal 0
1 ABIN208936 ELISA Func IHC IHC (p) WB Mouse IgG1 Log in to see 0

General

Antigen Lipopolysaccharide Binding Protein (LBP) Antibodies
Reactivity Human
(82), (63), (29), (11), (9), (7), (4), (3), (3), (2), (2), (1)
Host Mouse
(83), (35), (27), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This LBP antibody is un-conjugated
(8), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(102), (72), (43), (27), (18), (17), (9), (9), (5), (5), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-LBP Antibody

Target Details LBP Application Details Handling References for anti-LBP antibody (ABIN343175) Images
Specificity Human LBP (Lipopolysaccaride binding protein). The antibody don't block LPS binding to membrane bound CD14.
Cross-Reactivity Cow (Bovine), Dog (Canine), Horse (Equine), Rabbit
Purification Protein A affinity column
Immunogen native human LBP
Clone BiG42
Isotype IgG1
Plasmids, Primers & others

Target Details LBP

Product Details anti-LBP Antibody Application Details Handling References for anti-LBP antibody (ABIN343175) Images back to top
Antigen
Alternative Name Lipopolysaccharide (LPS)-Binding Protein (LBP) (LBP Antibody Abstract)
Background Background: Natural Lipopolysccaride Binding Protein (LBP) is a 58KD glycoprotein produced in liver. It binds at lipid A of LPS with high affinity (10-9M) and reduced the cellular LPS effects at CD14+ cells (IL1ß, IL6, TNFα). It acts as opsonin for GRAM negative cells, LPS, neutrophiles and granulocytes.
Molecular Weight ~58kDa
Gene ID 3929
NCBI Accession NP_004130
UniProt P18428
Pathways TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process

Application Details

Product Details anti-LBP Antibody Target Details LBP Handling References for anti-LBP antibody (ABIN343175) Images back to top
Application Notes ELISA, Immune histology at paraffin sections, LBP inhibition studies, Western Blot. No inhibition of LPS binding to membrane bound CD14 Binding titre at human LBP- ELISA: 1:10.000
Restrictions For Research Use only

Handling

Product Details anti-LBP Antibody Target Details LBP Application Details References for anti-LBP antibody (ABIN343175) Images back to top
Format Lyophilized
Reconstitution Reconstitute with bidistilled water
Concentration 1 mg/mL
Buffer PBS, pH 7.12
Preservative Without preservative
Storage -20 °C,-80 °C

References for anti-LBP antibody (ABIN343175)

Product Details anti-LBP Antibody Target Details LBP Application Details Handling Images back to top
Product cited in:

Eckert, Kim, Kim, Gürtler, Oh, Sur, Lundvall, Hamann, van der Ploeg, Pickkers, Giamarellos-Bourboulis, Kubarenko, Weber, Kabesch, Kumpf, An, Lee, Schumann: "The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity." in: Immunity, Vol. 39, Issue 4, pp. 647-60, 2013

Rahman, Lecchi, Avallone, Roccabianca, Sartorelli, Ceciliani: "Lipopolysaccharide-binding protein: Local expression in bovine extrahepatic tissues." in: Veterinary immunology and immunopathology, 2010

Ren, Jin, Leung: "Local expression of lipopolysaccharide-binding protein in human gingival tissues." in: Journal of periodontal research, Vol. 39, Issue 4, pp. 242-8, 2004

Images

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Supplier Images
Western Blotting (WB) image for anti-Lipopolysaccharide Binding Protein (LBP) antibody (ABIN343175) anti-Lipopolysaccharide Binding Protein (LBP) antibody