anti-Human TANK-Binding Kinase 1 antibody for Immunohistochemistry

Recommended TANK-Binding Kinase 1 Antibody (supplied by: Log in to see )

Antigen
TANK-Binding Kinase 1 (TBK1) Antibodies
  • nak
  • t2k
  • TBK1
  • wu:fk70c05
  • zgc:136548
  • NAK
  • T2K
  • 1200008B05Rik
  • AI462036
  • AW048562
  • TANK binding kinase 1 L homeolog
  • TANK binding kinase 1
  • TANK-binding kinase 1
  • tbk1.L
  • TBK1
  • tbk1
  • Tbk1
Epitope
pSer172
19
18
17
11
7
7
5
4
4
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
132
84
49
27
26
10
10
9
8
5
5
4
3
2
2
2
2
1
1
Host
Rabbit
104
34
13
Clonality
Polyclonal
Conjugate
Un-conjugated
10
10
9
7
5
5
3
3
1
1
1
1
1
1
1
1
1
Application
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
133
69
61
31
24
18
9
6
3
2
2
2
1
Supplier
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Catalog No. ABIN6271546
$ 450.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
15.572235 ABIN3016268 IHC WB Rabbit Log in to see Polyclonal 0
12.572235 ABIN3187188 ELISA IHC Rabbit IgG Tyr699 Log in to see Polyclonal 0
10 ABIN1871368 ICC IHC WB Rabbit IgG AA 9-310 Log in to see Polyclonal 0
10 ABIN2913758 IF/ICC IHC IP WB Rabbit AA 9-310 Log in to see Polyclonal 0
9.972757 ABIN768998 IHC IHC (p) WB Rabbit IgG AA 539-588 Log in to see Polyclonal 0
9.972757 ABIN768997 IHC IHC (p) WB Rabbit IgG AA 74-123 Log in to see Polyclonal 0
9.972757 ABIN213888 IHC IHC (p) WB Mouse IgG1, kappa AA 563-577 Log in to see 108A429  0
9.972757 ABIN6265480 ELISA ICC IF IHC WB Rabbit IgG Log in to see Polyclonal 0
9.972757 ABIN3029094 IHC ELISA WB Rabbit Ig Fraction AA 150-181 Log in to see Polyclonal 0
6.9727573 ABIN2625929 ELISA IHC IHC (p) WB Goat AA 514-527 Log in to see Polyclonal 0
6.9727573 ABIN2470805 IHC WB Mouse IgG Log in to see 72B587 0
4 ABIN1875027 IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN2625928 IHC IHC (p) WB Rabbit IgG AA 577-590 Log in to see Polyclonal 0
1 ABIN1450668 IHC ELISA Rabbit IgG AA 138-187 Log in to see Polyclonal 0
1 ABIN2878398 ELISA IHC IHC (p) Rabbit IgG AA 138-187 Log in to see Polyclonal 0
1 ABIN1953648 IHC ELISA WB APC Rabbit IgG Ser172 Log in to see Polyclonal 0
1 ABIN1952776 IHC ELISA WB Alkaline Phosphatase (AP) Rabbit IgG Ser172 Log in to see Polyclonal 0
1 ABIN1956094 IHC ELISA WB FITC Rabbit IgG Ser172 Log in to see Polyclonal 0
1 ABIN1954947 IHC ELISA WB Biotin Rabbit IgG Ser172 Log in to see Polyclonal 0
1 ABIN1958421 IHC ELISA WB PE Rabbit IgG Ser172 Log in to see Polyclonal 0

General

Antigen TANK-Binding Kinase 1 (TBK1) Antibodies
Epitope pSer172
(19), (18), (17), (11), (7), (7), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(132), (84), (49), (27), (26), (10), (10), (9), (8), (5), (5), (4), (3), (2), (2), (2), (2), (1), (1)
Host Rabbit
(104), (34), (13)
Clonality
Polyclonal
Conjugate Un-conjugated
(10), (10), (9), (7), (5), (5), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
(133), (69), (61), (31), (24), (18), (9), (6), (3), (2), (2), (2), (1)
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Product details

Target Details Application Details Handling Images
Specificity TBK1 (Phospho-Ser172) Antibody detects endogenous levels of TBK1 only when phosphorylated at Ser172
Cross-Reactivity Human, Mouse (Murine)
Purification The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Immunogen A synthesized peptide derived from human TBK1 (Phospho-Ser172)
Isotype IgG

Target Details

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Antigen
Alternative Name TBK1 (TBK1 Antibody Abstract)
Background

Description: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates and activates AKT1 (PubMed:21464307). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125).

Gene: TBK1

Molecular Weight 84kDa
Gene ID 29110
UniProt Q9UHD2
Pathways TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades

Application Details

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Application Notes WB 1:1000-3000, IHC 1:50-1:200
Restrictions For Research Use only

Handling

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Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20 °C.Stable for 12 months from date of receipt
Expiry Date 12 months

Images

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Supplier Images
Immunohistochemistry (IHC) image for anti-TANK-Binding Kinase 1 (TBK1) (pSer172) antibody (ABIN6271546) ABIN6271547 at 1/200 staining Human tonsil tissue sections by IHC-P. The tissue was f...
Immunohistochemistry (IHC) image for anti-TANK-Binding Kinase 1 (TBK1) (pSer172) antibody (ABIN6271546) ABIN6271547 at 1/200 staining Mouse kidney tissue sections by IHC-P. The tissue was f...
Immunohistochemistry (IHC) image for anti-TANK-Binding Kinase 1 (TBK1) (pSer172) antibody (ABIN6271546) ABIN6271547 at 1/200 staining Rat lung tissue sections by IHC-P. The tissue was forma...
Western Blotting (WB) image for anti-TANK-Binding Kinase 1 (TBK1) (pSer172) antibody (ABIN6271546) Western blot analysis of TBK1 (Phospho-Ser172) using PMA treated HeLa whole cell lysates